Left cardiac remodelling assessed by echocardiography is associated with rho-kinase activation in long-distance runners

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dc.article.number118
dc.catalogadorjca
dc.contributor.authorContreras Briceño, Felipe
dc.contributor.authorVega, Julián
dc.contributor.authorMandiola, Jorge
dc.contributor.authorOcaranza, María Paz
dc.contributor.authorHerrera, Sebastián
dc.contributor.authorSalinas, Manuel
dc.contributor.authorFernández, Rodrigo
dc.contributor.authorJalil, Jorge E.
dc.contributor.authorLavandero, Sergio
dc.contributor.authorChiong, Mario
dc.contributor.authorGodoy, Paz
dc.contributor.authorCastro, Pablo F.
dc.contributor.authorSitges, Marta
dc.contributor.authorGabrielli, Luigi
dc.date.accessioned2024-04-15T08:00:35Z
dc.date.available2024-04-15T08:00:35Z
dc.date.issued2021
dc.description.abstractThis single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDRs) during the training period before a marathon race. Thirty-six healthy male LDRs (37.0 ± 5.3 years; 174.0 ± 7.0 height; BMI: 23.8 ± 2.8;.V O2-peak: 56.5 ± 7.3 mL·kg−1·min−1) were separated into two groups according to previous training level: high-training (HT, n = 16) ≥ 100 km·week−1 and low-training (LT, n = 20) ≥ 70 and < 100 km·week−1. Also, twenty-one healthy nonactive subjects were included as a control group (CTR). A transthoracic echocardiography was performed and ROCK activity levels in circulating leukocytes were measured at rest (48 h without exercising) the week before the race. The HT group showed a higher left ventricular mass index (LVMi) and left atrial volume index (LAVi) than other groups (p < 0.05, for both); also, higher levels of ROCK activity were found in LDRs (HT = 6.17 ± 1.41 vs. CTR = 1.64 ± 0.66 (p < 0.01); vs. LT = 2.74 ± 0.84; (p < 0.05)). In LDRs a direct correlation between ROCK activity levels and LVMi (r = 0.83; p < 0.001), and LAVi (r = 0.70; p < 0.001) were found. In conclusion, in male competitive long-distance runners, the load of exercise implicated in marathon training is associated with ROCK activity levels and the left cardiac remodelling process assessed by echocardiography.
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderFondo Nacional de Ciencia y Tecnología
dc.description.funderFONDAP
dc.fechaingreso.objetodigital2024-12-17
dc.format.extent77 páginas
dc.fuente.origenScopus
dc.identifier.doi10.3390/jcdd8100118
dc.identifier.eissn23083425
dc.identifier.isbn978-1-58603-917-2
dc.identifier.issn2308-3425
dc.identifier.pubmedidMEDLINE:34800746
dc.identifier.scopusidSCOPUS_ID:85116295653
dc.identifier.urihttps://doi.org/10.3390/jcdd8100118
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/85101
dc.identifier.wosidWOS:000913992300001
dc.information.autorucEscuela de Medicina; Contreras Briceño, Felipe; 0000-0002-0674-7506; 1011730
dc.issue.numero10
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final77
dc.pagina.inicio68
dc.publisherWiley
dc.relation.ispartofARQ
dc.revistaJournal of Cardiovascular Development and Disease
dc.rightsacceso abierto
dc.subjectAthlete’s heart
dc.subjectCardiac biomarkers
dc.subjectEchocardiography
dc.subjectExercise
dc.subjectFunctional cardiac capacity
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods12 Responsible Consumption and Production
dc.subject.ods13 Climate Action
dc.subject.odspa12 Producción y consumo responsable
dc.subject.odspa13 Acción por el clima
dc.titleLeft cardiac remodelling assessed by echocardiography is associated with rho-kinase activation in long-distance runners
dc.typeartículo
dc.volumen8
sipa.codpersvinculados1011730
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-04-2024
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