Thrombin generation in platelet-poor plasma is normal in patients with hereditary mucoputaneous haemorrhages

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dc.contributor.authorQuiroga, T
dc.contributor.authorGoycoolea, M
dc.contributor.authorGiesen, PLA
dc.contributor.authorMorales, M
dc.contributor.authorMuñoz, B
dc.contributor.authorAranda, E
dc.contributor.authorRodríguez, S
dc.contributor.authorPanes, O
dc.contributor.authorMartínez, C
dc.contributor.authorPereira, J
dc.contributor.authorMezzano, D
dc.date.accessioned2025-01-21T01:09:57Z
dc.date.available2025-01-21T01:09:57Z
dc.date.issued2003
dc.description.abstractMild hereditary bleeding disorders presenting with mucocutaneous haemorrhages are usually difficult to diagnose. We measured thrombin generation in platelet-poor plasma (TG-PPP) in 206 patients with a clinically unequivocal bleeding tendency: 45 with von Willebrand disease (vWD), 49 with platelet aggregation/secretion defects (PASD), 10 with a combination of both and 102 who did not fit the diagnostic criteria for any known haemostatic disorder. TG-PPP was not significantly different from controls in all patient groups, indicating that an abnormality in the plasmatic clotting system is unlikely to contribute to the bleeding in patients with type 1 vWD and PASD. In patients with undiagnosed mild hereditary bleeding disorders, there must be other mechanisms which explain the abnormal haemorrhagic tendency, most likely as yet unrecognized defects in platelet-vessel wall interaction. As a next step we plan to investigate thrombin generation in PRP. Copyright (C) 2003 S. Karger AG, Basel.
dc.fuente.origenWOS
dc.identifier.doi10.1159/000071639
dc.identifier.issn1424-8832
dc.identifier.urihttps://doi.org/10.1159/000071639
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96636
dc.identifier.wosidWOS:000184774300006
dc.issue.numero1
dc.language.isoen
dc.pagina.final35
dc.pagina.inicio30
dc.revistaPathophysiology of haemostasis and thrombosis
dc.rightsacceso restringido
dc.subjectthrombin generation
dc.subjectmucocutaneous haemorrhages
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThrombin generation in platelet-poor plasma is normal in patients with hereditary mucoputaneous haemorrhages
dc.typeartículo
dc.volumen33
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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