CO-TRANSMISSION IN THE RAT VAS-DEFERENS - POSTJUNCTIONAL SYNERGISM OF NORADRENALINE AND ADENOSINE 5'-TRIPHOSPHATE

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dc.contributor.authorHUIDOBROTORO, JP
dc.contributor.authorPARADA, S
dc.date.accessioned2025-01-23T19:24:54Z
dc.date.available2025-01-23T19:24:54Z
dc.date.issued1988
dc.description.abstractIn the isolated prostatic half of the rat vas deferens, joint application of noradrenaline (NA) and adenosine 5''-triphosphate (ATP) produced a contractile response whose magnitude was greatly larger than the addition of the tension generated by the application of each agent alone. The effect of ATP was mimicked by two non-hydrolyzable ATP analogs, but not by GTP, AMP or adenosine. In sympathectomized rats, ATP potentiated NA effects, increasing both the peak tension and the duration of the vas deferens contractile response. The synergism was concentration related. Prazosin antagonized the NA synergism but not the ATP response. Likewise, desensitization of the P2-purinoceptor blocked the ATP synergism without modifying the NA-induced contraction.
dc.fuente.origenWOS
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99415
dc.identifier.wosidWOS:A1988M253900010
dc.issue.numero3
dc.language.isoen
dc.pagina.final344
dc.pagina.inicio339
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCO-TRANSMISSION IN THE RAT VAS-DEFERENS - POSTJUNCTIONAL SYNERGISM OF NORADRENALINE AND ADENOSINE 5'-TRIPHOSPHATE
dc.typeartículo
dc.volumen85
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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