Prophylactic fluconazole protocol in very low birth weight infants: invasive candidiasis prevention in a Latin American neonatal intensive care unit

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dc.contributor.authorValenzuela-Stutman, Daniela
dc.contributor.authorRomero, Andrea Maccioni
dc.contributor.authorAstudillo, Patricio
dc.date.accessioned2025-01-20T20:11:28Z
dc.date.available2025-01-20T20:11:28Z
dc.date.issued2023
dc.description.abstractObjectiveTo evaluate the effect of prophylactic fluconazole for very low birth weight infants (VLBWI) in a neonatal intensive care unit (NICU) with a 7.8% incidence of invasive candidiasis (IC).Study designInterventional pre-post cohort study comparing 2 years with and without fluconazole prophylaxis protocol (2016-2018 = 228 infants and 2019-2021 = 125 infants). Fluconazole was administered to all extremely low birth weight infants (ELBWI) and infants with BW 1001-1500 g with risk factors or positive carrier cultures. Liver function tests were performed weekly.ResultsThe incidence of IC decreased from 7.8% to 2.4% (OR:0.3, p = 0.05) with the use of prophylactic fluconazole for VLBWI and in ELBWI decreased from 16,7% to 3,7% (OR:0.1, p = 0.04). No significant differences were seen in mortality.ConclusionsFluconazole is a safe, effective, and feasible strategy to prevent IC in a Latin American country.
dc.fuente.origenWOS
dc.identifier.doi10.1038/s41372-023-01699-0
dc.identifier.eissn1476-5543
dc.identifier.issn0743-8346
dc.identifier.urihttps://doi.org/10.1038/s41372-023-01699-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92148
dc.identifier.wosidWOS:000998238300001
dc.issue.numero9
dc.language.isoen
dc.pagina.final1144
dc.pagina.inicio1139
dc.revistaJournal of perinatology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleProphylactic fluconazole protocol in very low birth weight infants: invasive candidiasis prevention in a Latin American neonatal intensive care unit
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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