Syndecan-1 expression is down-regulated during myoblast terminal differentiation - Modulation by growth factors and retinoic acid

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dc.contributor.authorLarrain, J
dc.contributor.authorCizmeciSmith, G
dc.contributor.authorTroncoso, V
dc.contributor.authorStahl, RC
dc.contributor.authorCarey, DJ
dc.contributor.authorBrandan, E
dc.date.accessioned2025-01-21T01:33:14Z
dc.date.available2025-01-21T01:33:14Z
dc.date.issued1997
dc.description.abstractSyndecan-1 is an integral membrane proteoglycan involved in the interaction of cells with extracellular matrix proteins and growth factors. It is transiently expressed in several condensing mesenchymal tissues after epithelial induction. In this study we evaluated the expression of syndecan-1 during skeletal muscle differentiation. The expression of syndecan-1 as determined by Northern blot analyses and immunofluorescence microscopy is down-regulated during differentiation. The transcriptional activity of a syndecan-1 promoter construct is also down-regulated in differentiating muscle cells. The decrease in syndecan-1 gene expression is not dependent on the presence of E-boxes, binding sites for the MyoD family of transcription factors in the promoter region, or myogenin expression. Deletion of the region containing the E-boxes or treatment of differentiating cells with sodium butyrate, an inhibitor of myogenin expression, had no effect on syndecan-1 expression. Basic fibroblast growth factor and transforming growth factor type beta, which are inhibitors of myogenesis, had little effect on syndecan-1 expression. When added together, however, they induced syndecan-1 expression. Retinoic acid, an inducer of myogenesis, inhibited syndecan-1 expression and abolished the effect of the growth factors. These results indicate that syndecan-1 expression is down-regulated during myogenesis and that growth factors and retinoic acid modulate syndecan-1 expression by a mechanism that is independent of myogenin.
dc.description.funderFIC NIH HHS
dc.fuente.origenWOS
dc.identifier.eissn1083-351X
dc.identifier.issn0021-9258
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97392
dc.identifier.wosidWOS:A1997XL73500075
dc.issue.numero29
dc.language.isoen
dc.pagina.final18424
dc.pagina.inicio18418
dc.revistaJournal of biological chemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSyndecan-1 expression is down-regulated during myoblast terminal differentiation - Modulation by growth factors and retinoic acid
dc.typeartículo
dc.volumen272
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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