Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis

Simple item page
dc.contributor.authorde Santiago, Pamela R.
dc.contributor.authorBlanco, Alejandro
dc.contributor.authorMorales, Fernanda
dc.contributor.authorMarcelain, Katherine
dc.contributor.authorHarismendy, Olivier
dc.contributor.authorHerrera, Marcela Sjoberg
dc.contributor.authorArmisen, Ricardo
dc.date.accessioned2025-01-20T23:55:29Z
dc.date.available2025-01-20T23:55:29Z
dc.date.issued2021
dc.description.abstractAims: Breast cancer is one of the leading causes of woman deaths worldwide, being a major public health problem. It has been reported that the expression of the RNA-editing enzyme Adenosine Deaminase Acting on RNAs 1 (ADAR1) is upregulated in breast cancer, predicting poor prognosis in patients. A few reports in literature examine ADAR1 and long non-coding RNAs (lncRNAs) interplay in cancer and suggest key roles in cancer-related pathways. This study aimed to investigate whether ADAR1 could alter the expression levels of lncRNAs and explore how those changes are related to breast cancer biology.
dc.description.abstractMain methods: ADAR1 overexpression and knockdown studies were performed in breast cancer cell lines to analyze the effects over lncRNAs expression. Guilt-by-Association correlation analysis of the TCGA-BRCA cohort was performed to predict the function of the lncRNA LINC00944.
dc.description.abstractKey findings: Here, we show that LINC00944 is responsive to ADAR1 up- and downregulation in breast cancer cells. We found that LINC00944 expression has a strong relationship with immune signaling pathways. Further assessment of the TCGA-BRCA cohort showed that LINC00944 expression was positively correlated to tumor-infiltrating T lymphocytes and pro-apoptotic markers. Moreover, we found that LINC00944 expression was correlated to the age at diagnosis, tumor size, and estrogen and progesterone receptor expression. Finally, we show that low expression of LINC00944 is correlated to poor prognosis in breast cancer patients.
dc.description.abstractSignificance: Our study provides further evidence of the effect of ADAR1 over lncRNA expression levels, and on the participation of LINC00944 in breast cancer, suggesting to further investigate its potential role as prognostic biomarker.
dc.description.funderGovernment of Chile through Agencia Nacional de Investigacion y Desarrollo (ANID)
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.lfs.2020.118956
dc.identifier.eissn1879-0631
dc.identifier.issn0024-3205
dc.identifier.urihttps://doi.org/10.1016/j.lfs.2020.118956
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95091
dc.identifier.wosidWOS:000616204100009
dc.language.isoen
dc.revistaLife sciences
dc.rightsacceso restringido
dc.subjectBreast cancer
dc.subjectCancer
dc.subjectlncRNAs
dc.subjectLINC00944
dc.subjectADAR1
dc.subjectPrognosis
dc.subjectTumor-infiltrating lymphocytes
dc.subjectBioinformatics
dc.subjectGuilt by association analysis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImmune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis
dc.typeartículo
dc.volumen268
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas