Opening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration

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dc.article.number52
dc.catalogadorpau
dc.contributor.authorEspinoza Amador, Hilda Andrea
dc.contributor.authorFigueroa, Xavier
dc.date.accessioned2024-01-10T14:23:27Z
dc.date.available2024-01-10T14:23:27Z
dc.date.issued2023
dc.description.abstract© 2023, BioMed Central Ltd., part of Springer Nature.Endothelial cell migration is a key process in angiogenesis. Progress of endothelial cell migration is orchestrated by coordinated generation of Ca2+ signals through a mechanism organized in caveolar microdomains. Connexins (Cx) play a central role in coordination of endothelial cell function, directly by cell-to-cell communication via gap junction and, indirectly, by the release of autocrine/paracrine signals through Cx-formed hemichannels. However, Cx hemichannels are also permeable to Ca2+ and Cx43 can be associated with caveolin-1, a structural protein of caveolae. We proposed that endothelial cell migration relies on Cx43 hemichannel opening. Here we show a novel mechanism of Ca2+ signaling in endothelial cell migration. The Ca2+ signaling that mediates endothelial cell migration and the subsequent tubular structure formation depended on Cx43 hemichannel opening and is associated with the translocation of Cx43 with caveolae to the rear part of the cells. These findings indicate that Cx43 hemichannels play a central role in endothelial cell migration and provide new therapeutic targets for the control of deregulated angiogenesis in pathological conditions such as cancer.
dc.description.funderCONICYT
dc.description.funderFONDECYT
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.fechaingreso.objetodigital2024-06-04
dc.fuente.origenScopus
dc.identifier.doi10.1186/s13062-023-00408-3
dc.identifier.issn17456150
dc.identifier.scopusidSCOPUS_ID:85168820675
dc.identifier.urihttps://doi.org/10.1186/s13062-023-00408-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80098
dc.identifier.wosidWOS:001055421200001
dc.information.autorucFacultad de Ciencias Biológicas; Espinoza Amador, Hilda Andrea; S/I; 1031193
dc.information.autorucFacultad de Ciencias Biológicas; Figueroa, Xavier; 0000-0001-9656-9100; 1437
dc.language.isoen
dc.nota.accesoContenido completo
dc.publisherBioMed Central Ltd
dc.revistaBiology Direct
dc.rightsacceso abierto
dc.subjectAngiogenesis
dc.subjectCa2+signaling
dc.subjectConnexin hemichannels
dc.subjectEndothelial cells
dc.subjectMigration
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleOpening of Cx43-formed hemichannels mediates the Ca2+ signaling associated with endothelial cell migration
dc.typeartículo
dc.volumen18
sipa.codpersvinculados1031193
sipa.codpersvinculados1437
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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