Leptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women

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dc.contributor.authorKato, Sumie
dc.contributor.authorAbarzua-Catalan, Lorena
dc.contributor.authorTrigo, Cesar
dc.contributor.authorDelpiano, Ana
dc.contributor.authorSanhueza, Cristobal
dc.contributor.authorGarcia, Karen
dc.contributor.authorIbanez, Carolina
dc.contributor.authorHormazabal, Katherine
dc.contributor.authorDiaz, Daniela
dc.contributor.authorBranes, Jorge
dc.contributor.authorCastellon, Enrique
dc.contributor.authorBravo, Erasmo
dc.contributor.authorOwen, Gareth
dc.contributor.authorCuello, Mauricio
dc.date.accessioned2025-01-23T21:34:07Z
dc.date.available2025-01-23T21:34:07Z
dc.date.issued2015
dc.description.abstractThe evidence linking obesity with ovarian cancer remains controversial. Leptin is expressed at higher levels in obese women and stimulates cell migration in other epithelial cancers. Here, we explored the clinical impact of overweight/obesity on patient prognosis and leptin's effects on the metastatic potential of ovarian cancer cells. We assessed clinical outcomes in 70 ovarian cancer patients (33 healthy weight and 37 overweight) that were validated with an external cohort from The Cancer Genome Atlas (TCGA) database. Progression-free and overall survival rates were significantly decreased in overweight patients. Similarly, a worse overall survival rate was found in TCGA patients expressing higher leptin/OB-Rb levels. We explored serum and ascites leptin levels and OB-Rb expression in our cohort. Serum and ascites leptin levels were higher in overweight patients experiencing worse survival. OB-Rb was more highly expressed in ascites and metastases than in primary tumors. Leptin exposure increased cancer cell migration/invasion through leptin-mediated activation of JAK/STAT3, PI3/AKT and RhoA/ROCK and promoted new lamellipodial, stress-fiber and focal adhesion formation. Leptin also contributed to the maintenance of stemness and the mesenchymal phenotype in ovarian cancer cells. Our findings demonstrate that leptin stimulated ovarian cancer cell migration and invasion, offering a potential explanation for the poor prognosis among obese women.
dc.fuente.origenWOS
dc.identifier.eissn1949-2553
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101529
dc.identifier.wosidWOS:000360969200034
dc.issue.numero25
dc.language.isoen
dc.pagina.final21119
dc.pagina.inicio21100
dc.revistaOncotarget
dc.rightsacceso restringido
dc.subjectleptin
dc.subjectovary
dc.subjectneoplasia
dc.subjectmetastasis
dc.subjectobesity
dc.subject.ods03 Good Health and Well-being
dc.subject.ods02 Zero Hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleLeptin stimulates migration and invasion and maintains cancer stem-like properties in ovarian cancer cells: an explanation for poor outcomes in obese women
dc.typeartículo
dc.volumen6
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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