Myokine Secretion Dynamics and Their Role in Critically Ill Patients: A Scoping Review

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dc.article.number2892
dc.catalogadoraba
dc.contributor.authorJalil Contreras, Yorschua Frederick
dc.contributor.authorDamiani Rebolledo, L. Felipe
dc.contributor.authorGarcía Valdés, Patricio
dc.contributor.authorBasoalto Escobar, Roque Ignacio
dc.contributor.authorGallastegui Guajardo, Julen Manuel
dc.contributor.authorGutiérrez Arias, Ruvistay
dc.date.accessioned2025-05-16T20:03:11Z
dc.date.available2025-05-16T20:03:11Z
dc.date.issued2025
dc.description.abstractBackground/Objectives: Myokines can modulate organ function and metabolism, offering a protective profile against ICU complications beyond preventing local muscle wasting. This scoping review aims to explore and summarize the evidence regarding the secretion of myokines and their potential local or systemic effects in critically ill patients. Methods: A scoping review following Joana Briggs Institute recommendations was conducted. A systematic search of MEDLINE (Ovid), Embase (Ovid), CENTRAL, CINAHL (EBSCOhost), WoS, and Scopus was conducted from inception to February 2023. We included primary studies evaluating myokine secretion/concentration in critically ill adults undergoing physical rehabilitation interventions. Two independent reviewers performed study selection and data extraction. Results: Seventeen studies published between 2012 and 2023 were included. Most were randomized clinical trials (47%). Physical rehabilitation interventions included electrical muscle stimulation, as well as passive and active mobilization, delivered alone or combined, in single or daily sessions lasting 20–60 min. Twelve studies (70%) evaluated interleukin-6, while interleukin-10, tumour necrosis factor-α, Interleukin-8, and myostatin were also commonly studied. Thirteen studies (76%) reported changes in myokine secretion or gene expression, although no clear concentration change pattern emerged. Myokines involved in muscle protein synthesis and breakdown may protect against muscle waste and weakness. Conclusions: The study of myokine dynamics in critically ill patients highlights the systemic impact of physical rehabilitation. This emerging field has grown in interest over the past decade, offering significant research potential. However, challenges such as study design, small sample sizes, and variability in physical therapy protocols hinder a comprehensive understanding of myokine responses.
dc.format.extent22 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/jcm14092892
dc.identifier.eissn2077-0383
dc.identifier.urihttps://doi.org/10.3390/jcm14092892
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104356
dc.information.autorucDepartamento de Ciencias de la Salud; Jalil Contreras, Yorschua Frederick; 0000-0002-4993-7158; 1079709
dc.information.autorucDepartamento de Ciencias de la Salud; Damiani Rebolledo, L. Felipe; 0000-0002-8338-0488; 237645
dc.information.autorucDepartamento de Ciencias de la Salud; García Valdés, Patricio; S/I; 1006675
dc.information.autorucEscuela de Medicina; Basoalto Escobar, Roque Ignacio; 0000-0002-8908-7397; 1010703
dc.information.autorucDepartamento de Ciencias de la Salud; Gallastegui Guajardo, Julen Manuel; S/I; 1135780
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaJournal of Clinical Medicine
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCritical care
dc.subjectCritical illness
dc.subjectMyokine
dc.subjectMuscle contraction
dc.subjectRehabilitation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleMyokine Secretion Dynamics and Their Role in Critically Ill Patients: A Scoping Review
dc.typeartículo
dc.volumen14
sipa.codpersvinculados1079709
sipa.codpersvinculados237645
sipa.codpersvinculados1006675
sipa.codpersvinculados1010703
sipa.codpersvinculados1135780
sipa.trazabilidadORCID;2025-05-07
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