ULTRASTRUCTURE OF MESOTHELIAL REGENERATION AFTER INTRAPERITONEAL INJECTION OF ASBESTOS FIBERS ON RAT OMENTUM
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1991
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Abstract
In order to describe the ultrastructural features of the early phases of regenerating mesothelium in rat peritoneum, 69 cases were examined after intraperitoneal injection of 0.05-15 mg crocidolite, chrysotile B and other mineral and synthetic fibers. The findings show the presence of intermediate or transition cells between proliferating submesothelial connective tissue cells bearing the ultrastructural phenotype of myofibroblasts and mature fully regenerated mesothelium. Our results and data accumulated in the literature provide strong support for the hypothesis of submesothelial cell origin for regenerating mesothelium.
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Keywords
MESOTHELIUM, ASBESTOS, MESOTHELIOMA, CARCINOGENESIS, MYOFIBROBLASTS