Reactance inversion in moderate to severe persistent asthma: low birth weight, prematurity effect, and bronchodilator response

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dc.contributor.authorVera, Ramiro Gonzalez
dc.contributor.authorGrell, Alberto Vidal
dc.contributor.authorCastro-Rodriguez, Jose A.
dc.contributor.authorMontenegro, Maria A. Palomino
dc.contributor.authorYarur, Alejandra Mendez
dc.date.accessioned2025-01-20T17:07:32Z
dc.date.available2025-01-20T17:07:32Z
dc.date.issued2024
dc.description.abstractIntroductionReactance inversion (RI) has been associated with impaired peripheral airway function in persistent asthma. However, there is little to no data about the difference between asthmatic children with and without RI. This study aimed to detect clinical and lung function differences in moderate-severe asthmatic children with and without RI.MethodsThis study was conducted between 2021 and 2022 in asthmatic school-age children. Impulse oscillometry (IOS) and spirometry were performed according to ATS/ERS standards.ResultsA total of 62 patients, with a mean age of 8.4 years, 54.8% were males and were divided into three groups: group 1 (32.3%) with no RI, group 2 (27.4%) with RI but disappearing after bronchodilator test and group 3 (40.3%) with persistent RI after bronchodilator test. Children in groups 2 and 3 had significantly lower birth weights than in group 1. Group 2 had lower gestational age compared to group 1. FEV1 and FEF25-75 of forced vital capacity were significantly lower in groups 2 and 3. In group 3, R5, AX, R5-20, and R5-R20/R5 ratios were significantly higher. Bronchodilator responses (BDR) in X5c, AX, and R5-R20 were significantly different between groups and lower in group 3.ConclusionRI is frequently found in children with moderate-severe persistent asthma, particularly in those with a history of prematurity or low birth weight. In some patients, RI disappears after the bronchodilator test; however, it, persists in those with the worst pulmonary function. RI could be a small airway dysfunction marker.
dc.fuente.origenWOS
dc.identifier.doi10.1080/02770903.2024.2324865
dc.identifier.eissn1532-4303
dc.identifier.issn0277-0903
dc.identifier.urihttps://doi.org/10.1080/02770903.2024.2324865
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90866
dc.identifier.wosidWOS:001180419500001
dc.issue.numero9
dc.language.isoen
dc.pagina.final1082
dc.pagina.inicio1076
dc.revistaJournal of asthma
dc.rightsacceso restringido
dc.subjectAsthma
dc.subjectlow birth weight
dc.subjectlung function
dc.subjectoscillometry
dc.subjectprematurity
dc.subjectschool-age children
dc.subjectreactance inversion
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReactance inversion in moderate to severe persistent asthma: low birth weight, prematurity effect, and bronchodilator response
dc.typeartículo
dc.volumen61
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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