Biochemical predictors of cardiac rhythm at 1 year follow-up in patients with non-valvular atrial fibrillation

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dc.contributor.authorAcevedo, Monica
dc.contributor.authorCorbalan, Ramon
dc.contributor.authorBraun, Sandra
dc.contributor.authorPereira, Jaime
dc.contributor.authorGonzalez, Ilse
dc.contributor.authorNavarrete, Carlos
dc.date.accessioned2025-01-20T23:58:14Z
dc.date.available2025-01-20T23:58:14Z
dc.date.issued2012
dc.description.abstractC-reactive protein (CRP) is increased in patients with atrial fibrillation (AF) and it might predict the lack of sinus rhythm maintenance in the long term follow-up. Scarce data have been reported relating endothelial dysfunction and/or haemostatic or platelet markers to sinus rhythm maintenance in AF patients. We aimed to determine whether some biochemical markers including soluble thrombomodulin (sTM), soluble P-selectin, thrombin-antithrombin (TAT) complex and CRP levels could predict sinus rhythm maintenance at 1 year follow-up in non-valvular AF patients. 130 patients (70 males, mean age 67 +/- A 13 years) with newly diagnosed AF na < ve of antithrombotic or antiplatelet therapy were studied. Baseline CRP, P-selectin, sTM and TAT levels were compared to those of 20 matched-healthy subjects in sinus rhythm. AF patients had significantly higher plasma CRP (10.5 +/- A 2.2 vs 3.25 +/- A 0.3 mg/l, p = 0.001), P-selectin (219 +/- A 141 vs 126 ng/ml, p = 0.01), and TAT (54 +/- A 237 vs 2.7 +/- A 3.3 ng/l, p = 0.001) levels compared with controls. Soluble TM levels, although higher than controls, did not reach statistical significance. Multivariate regression analyses showed that elevated CRP (OR = 4.8, p = 0.02) and sTM (OR = 1.05, p = 0.04) were the only two predictors of lack of sinus rhythm at 1 year follow-up. An altered inflammatory, haemostatic, endothelial and platelet environment exists in newly diagnosed AF patients. CRP and sTM levels might be used as biochemical markers to predict the status of cardiac rhythm at 1 year follow-up in some AF patients.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11239-012-0690-1
dc.identifier.eissn1573-742X
dc.identifier.issn0929-5305
dc.identifier.urihttps://doi.org/10.1007/s11239-012-0690-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95238
dc.identifier.wosidWOS:000303508600012
dc.issue.numero4
dc.language.isoen
dc.pagina.final388
dc.pagina.inicio383
dc.revistaJournal of thrombosis and thrombolysis
dc.rightsacceso restringido
dc.subjectAtrial fibrillation
dc.subjectC-reactive protein
dc.subjectSoluble thrombomodulin
dc.subjectCardiac biomarkers
dc.subjectCardiac rhythm
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBiochemical predictors of cardiac rhythm at 1 year follow-up in patients with non-valvular atrial fibrillation
dc.typeartículo
dc.volumen33
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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