Universal Access to On-Demand Treatment of Patients with Hereditary Angioedema, the Chilean Experience

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dc.contributor.authorEscobar, Juan J.
dc.contributor.authorAguirre, Joaquin
dc.contributor.authorIbanez, Samuel
dc.contributor.authorCid, Barbara J.
dc.contributor.authorCampillay, Rolando
dc.contributor.authorGallardo, Ana Maria
dc.contributor.authorGrau, Masumi
dc.contributor.authorHoyos-Bachiloglu, Rodrigo
dc.date.accessioned2025-01-20T17:20:41Z
dc.date.available2025-01-20T17:20:41Z
dc.date.issued2023
dc.description.abstractBackground: In Chile, patients with hereditary angioedema (HAE) type I and type II are protected under Ley Ricarte Soto (LRS), which guarantees access to on demand plasma-derived C1-INH (pdC1-INH) since 2018. We aimed to analyze the first 3 years of LRS.Methods: Review of the LRS database between 2018 and 2021.Results: During the study period, 154 patients were covered by LRS, with an estimated prevalence of HAE in Chile at 0.8:100,000 inhabitants. A delay in diagnosis of 22 years was noted, 50 patients received epinephrine during an attack before the diagnosis of HAE. Mean number of attacks per year was 8, with 50% of adults and 42% of children experiencing more than 1 attack per month.Conclusion: Disease awareness must improve to reduce the diagnostic delay of HAE. Long-term prophylactic medications should be included in LRS to treat patients with high attack rates and control the costs of frequent on-demand treatment with pdC1-INH.
dc.fuente.origenWOS
dc.identifier.doi10.1089/ped.2023.0083
dc.identifier.eissn2151-3228
dc.identifier.issn2151-321X
dc.identifier.urihttps://doi.org/10.1089/ped.2023.0083
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91434
dc.identifier.wosidWOS:001129538300003
dc.issue.numero4
dc.language.isoen
dc.pagina.final132
dc.pagina.inicio130
dc.revistaPediatric allergy immunology and pulmonology
dc.rightsacceso restringido
dc.subjectangioedema
dc.subjectepidemiology
dc.subjectplasma derived C1 inhibitor
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUniversal Access to On-Demand Treatment of Patients with Hereditary Angioedema, the Chilean Experience
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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