Age-Dependent Changes in the Activation and Regulation of Microglia

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dc.catalogadoryvc
dc.contributor.authorVon Bernhardi Montgomery, Rommy Edth B.
dc.contributor.authorCornejo Castillo, Francisca Alejandra
dc.date.accessioned2025-03-05T15:01:40Z
dc.date.available2025-03-05T15:01:40Z
dc.date.issued2016
dc.description.abstractAs we age, a large number of physiological and molecular changes affect the normal functioning of cells, tissues, and the organism as a whole. One of the main changes is the establishment of a state of systemic inflammatory activation, which has been termed "inflamm-aging"; a mild chronic inflammation of the aging organism that reduces the ability to generate an efficient response against stressor stimuli. As any other system, the nervous system undergoes these aging-related changes; the neuroinflammatory state depends mainly on the dysregulated activation of microglia, the innate immune cells of the central nervous system (CNS) and the principal producers of reactive oxygen species. As the brain ages, microglia acquire a phenotype that is increasingly inflammatory and cytotoxic, generating a hostile environment for neurons. There is mounting evidence that this process facilitates development of neurodegenerative diseases, for which the greatest risk factor is age. In this chapter, we will review key aging-associated changes occurring in the central nervous system, focusing primarily on the changes that occur in aging microglia, the inflammatory and oxidative stressful environment they establish, and their impaired regulation. In addition, we will discuss the effects of aged microglia on neuronal function and their participation in the development of neurodegenerative pathologies such as Parkinson's and Alzheimer's diseases.
dc.description.funderANID FONDECYT No. 1131025
dc.description.funderCONICYT 21120013
dc.fechaingreso.objetodigital2025-03-05
dc.format.extent22 páginas
dc.fuente.origenRepositorio UC
dc.identifier.doi10.1007/978-3-319-40764-7_10
dc.identifier.scopusidScopus_ID: 2-s2.0-85211127371
dc.identifier.urihttps://doi.org/10.1007/978-3-319-40764-7_10
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102366
dc.identifier.wosidWoS_ID: 000400932800010
dc.information.autorucEscuela de Medicina; Von Bernhardi Montgomery Rommy Edth B.; S/I; 62523
dc.information.autorucEscuela de Medicina; Cornejo Castillo Francisca Alejandra; 0000-0001-9280-3430; 156096
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final226
dc.pagina.inicio205
dc.publisherSpringer International Publishing Switzerland
dc.relation.ispartofGlial Cells in Health and Disease of the CNS. Editors Rommy von Bernhardi. The Springer International Publishing AG, Cham, xi, 348 p. 2016
dc.relation.ispartofseriesAdvances in Experimental Medicine and Biology
dc.rightsacceso restringido
dc.subjectAging
dc.subjectCytokines
dc.subjectMicroglia
dc.subjectNeuroinflammation
dc.subjectNeurodegenerative diseases
dc.subject.ddc610
dc.subject.deweyMedicina y salud
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAge-Dependent Changes in the Activation and Regulation of Microglia
dc.typecapítulo de libro
dc.volumen949
sipa.codpersvinculados62523
sipa.codpersvinculados156096
sipa.trazabilidadConveris;21-07-2020
sipa.trazabilidadRepositorio UC;08-07-2021
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