GLOMERULAR LOCALIZATION OF PLATELET FACTOR-IV IN STREPTOCOCCAL NEPHRITIS

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dc.contributor.authorMEZZANO, S
dc.contributor.authorBURGOS, ME
dc.contributor.authorARDILES, L
dc.contributor.authorOLAVARRIA, F
dc.contributor.authorCONCHA, M
dc.contributor.authorCAORSI, I
dc.contributor.authorARANDA, E
dc.contributor.authorMEZZANO, D
dc.date.accessioned2025-01-23T19:22:09Z
dc.date.available2025-01-23T19:22:09Z
dc.date.issued1992
dc.description.abstractSince platelet factor 4 (PF4), a cationic (pI 7.6) platelet secretory protein, binds avidly to glomerular polyanions both in vitro and in vivo, and is implicated in neutrophil chemotaxis, we studied by indirect immunofluorescence microscopy the presence of PF4 deposits in glomeruli of patients with poststreptococcal nephritis (APSGN).
dc.description.abstractGoat antihuman PF4 serum was used as primary antibody and fluorescein-conjugated IgG fraction of rabbit antigoat IgG as second antibody. Controls consisted of nonimmune goat serum or anti-PF4 serum preabsorbed with human PF4, as primary antibodies. Glomerular deposits of PF4 were demonstrated in renal tissues obtained by biopsy in 14 of 20 patients studied; the deposits were particularly intense in 9 patients. PF4 was bound to the mesangium and to the capillary walls. There was a significant positive correlation between intraglomerular deposits of PF4 and the levels of proteinuria (p = 0.024). These findings provide further evidence for a role of platelets in the pathogenesis of APSGN and suggest that PF4 may contribute to alter the glomerular permeability in this disease.
dc.fuente.origenWOS
dc.identifier.issn0028-2766
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/98977
dc.identifier.wosidWOS:A1992HP31900011
dc.issue.numero1
dc.language.isoen
dc.pagina.final63
dc.pagina.inicio58
dc.revistaNephron
dc.rightsacceso restringido
dc.subjectPLATELET FACTOR-IV
dc.subjectSTREPTOCOCCAL NEPHRITIS
dc.subjectGLOMERULAR PERMEABILITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGLOMERULAR LOCALIZATION OF PLATELET FACTOR-IV IN STREPTOCOCCAL NEPHRITIS
dc.typeartículo
dc.volumen61
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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