Pannexin channel and connexin hemichannel expression in vascular function and inflammation

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dc.contributor.authorBegandt, Daniela.
dc.contributor.authorGood, Miranda E.
dc.contributor.authorKeller, Alex S.
dc.contributor.authorDeLalio, Leon J.
dc.contributor.authorRowley, Carol.
dc.contributor.authorIsakson, Brant E.
dc.contributor.authorFigueroa, Xavier
dc.date.accessioned2019-10-17T18:19:51Z
dc.date.available2019-10-17T18:19:51Z
dc.date.issued2017
dc.date.updated2019-10-14T18:34:58Z
dc.description.abstractAbstract Control of blood flow distribution and tissue homeostasis depend on the tight regulation of and coordination between the microvascular network and circulating blood cells. Channels formed by connexins or pannexins that connect the intra- and extracellular compartments allow the release of paracrine signals, such as ATP and prostaglandins, and thus play a central role in achieving fine regulation and coordination of vascular function. This review focuses on vascular connexin hemichannels and pannexin channels. We review their expression pattern within the arterial and venous system with a special emphasis on how post-translational modifications by phosphorylation and S-nitrosylation of these channels modulate their function and contribute to vascular homeostasis. Furthermore, we highlight the contribution of these channels in smooth muscle cells and endothelial cells in the regulation of vasomotor tone as well as how these channels in endothelial cells regulate inflammatory responses such as during ischemic and hypoxic conditions. In addition, this review will touch on recent evidence implicating a role for these proteins in regulating red blood cell and platelet function.
dc.fuente.origenBiomed Central
dc.identifier.citationBMC Cell Biology. 2017 Jan 17;18(Suppl 1):2
dc.identifier.doi10.1186/s12860-016-0119-3
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/26818
dc.identifier.wosidWOS:000403981800001
dc.issue.numeroNo. 2
dc.language.isoen
dc.pagina.final16
dc.pagina.inicio1
dc.revistaBMC Cell Biologyes_ES
dc.rightsacceso abierto
dc.rights.holderThe Author(s).
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.subject.otherEnfermedad cardiovasculares_ES
dc.subject.otherHomeostasises_ES
dc.subject.otherGlobulos rojoses_ES
dc.subject.otherPlaquetases_ES
dc.subject.otherBiología celulares_ES
dc.titlePannexin channel and connexin hemichannel expression in vascular function and inflammationes_ES
dc.typeartículo
dc.volumenVol. 18
sipa.codpersvinculados1437
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