Variation in patient management and outcomes for acute coronary syndromes in Latin America and North America

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dc.contributor.authorCohen, MG
dc.contributor.authorPacchiana, CM
dc.contributor.authorCorbalán, R
dc.contributor.authorPerez, JEI
dc.contributor.authorPonte, CI
dc.contributor.authorOropeza, ES
dc.contributor.authorDiaz, R
dc.contributor.authorPaolasso, E
dc.contributor.authorIzasa, D
dc.contributor.authorRodas, MA
dc.contributor.authorUrrutia, CE
dc.contributor.authorHarrington, RA
dc.contributor.authorTopol, EJ
dc.contributor.authorCaliff, RM
dc.date.accessioned2025-01-21T01:30:56Z
dc.date.available2025-01-21T01:30:56Z
dc.date.issued2001
dc.description.abstractBackground Although more than 9500 patients have been enrolled in molar clinical trials in Latin America, practice patterns in this region have rarely been examined. We sought to compare characteristics, resource utilization, and outcomes of patients treated For acute coronary syndromes in Latin America with those in North America.
dc.description.abstractMethods The Platelet IIb/IIIa in Unstable Angina: Receptor Suppression Using Integrilin Theraphy Trial (PURSUIT) enrolled 10,948 patients with non-ST-segment elevation acute coronary syndromes, including 585 in Latin America and 4358 in North America. We analyzed regional differences in patient groups, treatment patterns, and outcomes and used logistic regression analysis to identify association of enrollment region and survival.
dc.description.abstractResults For patients in Latin America, the length of hospital stay was significantly longer (10 [7, 15] days vs 6 [4, 9], P<.001). Angiograms, angioplasty, and bypass surgery were significantly less common in Latin America (46.2%, 17.6%, and 11.3% vs 79.4%, 33.6%, and 19.4%, P<.001). Thirty-day death/myocardial infarction was not significantly higher, although mortality alone was significantly higher (6.8% vs 3.1%, P<.001). After adjustment for baseline characteristics, enrollment in Latin America remained on independent predictor for death at 30 days (odds ratio [OR] [95% confidence interval (CI)] 2.42 [1.60-3.67]) and persisted at 6 months (OR [95% CI] 2.5 [1.8-3.4]).
dc.description.abstractConclusions Latin American patients treated for acute coronary syndromes were managed less invasively and were twice as likely as their North American counterparts to die within 6 months. This mortality difference was not explained by imbalances in baseline risk.
dc.fuente.origenWOS
dc.identifier.doi10.1067/mhj.2001.113216
dc.identifier.issn0002-8703
dc.identifier.urihttps://doi.org/10.1067/mhj.2001.113216
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96935
dc.identifier.wosidWOS:000167321600015
dc.issue.numero3
dc.language.isoen
dc.pagina.final401
dc.pagina.inicio391
dc.revistaAmerican heart journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleVariation in patient management and outcomes for acute coronary syndromes in Latin America and North America
dc.typeartículo
dc.volumen141
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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