CORTICAL ABLATION REDUCES VERATRIDINE EVOKED RELEASE OF ENDOGENOUS GLUTAMATE FROM SUPERFUSED SUBSTANTIA-NIGRA SLICES

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dc.contributor.authorFIEDLER, J
dc.contributor.authorBUSTOS, G
dc.date.accessioned2025-01-23T19:22:48Z
dc.date.available2025-01-23T19:22:48Z
dc.date.issued1991
dc.description.abstractA brain slice superfusion system and HPLC coupled to fluorometric detection were used to study depolarization-evoked release of endogenous glutamate (Glu) and aspartate (Asp) from substantia nigra (SN) slices. Veratridine (15-25 mu-M) and K+ (50 mM) evoked both a Ca2+-dependent and Ca2+-independent release of Glu and Asp. However, the pattern of Glu release was different from that of Asp. In addition, cortical ablation significantly reduced the evoke release of Glu but not that of Asp. There results indicate the existence of SN of functional Glu- and Asp-releasing nerve terminals. Some of the Glu-enriched nerve terminals might belong to a cortico-nigral neuronal pathway.
dc.fuente.origenWOS
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99106
dc.identifier.wosidWOS:A1991EV96600025
dc.issue.numero1
dc.language.isoen
dc.pagina.final98
dc.pagina.inicio96
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subjectGLUTAMATE
dc.subjectASPARTATE
dc.subjectDEPOLARIZATION
dc.subjectRELEASE
dc.subjectSUBSTANTIA NIGRA
dc.subjectSLICE
dc.subjectCORTICAL ABLATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCORTICAL ABLATION REDUCES VERATRIDINE EVOKED RELEASE OF ENDOGENOUS GLUTAMATE FROM SUPERFUSED SUBSTANTIA-NIGRA SLICES
dc.typeartículo
dc.volumen122
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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