Potential of curcumin-loaded cubosomes for topical treatment of cervical cancer

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dc.contributor.authorVictorelli, Francesca Damiani
dc.contributor.authorManni, Livia Salvati
dc.contributor.authorBiffi, Stefania
dc.contributor.authorBortot, Barbara
dc.contributor.authorBuzza, Hilde Harb
dc.contributor.authorLutz-Bueno, Viviane
dc.contributor.authorHandschin, Stephan
dc.contributor.authorCalixto, Giovana
dc.contributor.authorMurgia, Sergio
dc.contributor.authorChorilli, Marlus
dc.contributor.authorMezzenga, Raffaele
dc.date.accessioned2024-01-10T13:45:14Z
dc.date.available2024-01-10T13:45:14Z
dc.date.issued2022
dc.description.abstractCervical cancer is one of the most common cancers affecting women worldwide. There are an estimated 570.000 new cases of cervical cancer each year and conventional treatments can cause severe side effects. In this work, we developed a platform for vaginal administration of lipophilic drugs for cervical cancer treatment. We formulated mucoadhesive cubosomes for the delivery of curcumin, a lipophilic drug for cervical cancer treatment, to increase its bioavailability and local absorption. This study tests the use of cubosomes for vaginal drug administration and assesses their potential efficiency using the CAM (chick embryo chorioallantoic membrane) model. SAXS (small-angle X-ray scattering), cryo-TEM (cryotransmission electron microscopy), and dynamic light scattering (DLS) were employed to characterise the system. With ex vivo permeation and retention studies, we find that the curcumin released from our system is retained in the vaginal mucosa. In vitro cytotoxicity assay and cellular uptake showed an increased cytotoxic effect of curcumin against HeLa cell line when incorporated into the cubosomes. The curcumin-loaded cubosomes also demonstrated an antiangiogenic effect evaluated in vivo by the CAM model. (c) 2022 The Author(s). Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.fechaingreso.objetodigital27-03-2024
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jcis.2022.04.031
dc.identifier.eissn1095-7103
dc.identifier.issn0021-9797
dc.identifier.urihttps://doi.org/10.1016/j.jcis.2022.04.031
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/79003
dc.identifier.wosidWOS:000793372900009
dc.information.autorucFacultad de Física; Harb Buzza, Hilde; S/I; 1232017
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final430
dc.pagina.inicio419
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.rightsacceso abierto
dc.subjectCubosomes
dc.subjectDOTAP
dc.subjectMucoadhesion
dc.subjectVaginal administration
dc.subjectCervical cancer
dc.subjectChorioallantoic membrane model
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePotential of curcumin-loaded cubosomes for topical treatment of cervical cancer
dc.typeartículo
dc.volumen620
sipa.codpersvinculados1232017
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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