Genetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America

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dc.contributor.authorFarias, Alberto Queiroz
dc.contributor.authorVilalta, Anna Curto
dc.contributor.authorZitelli, Patricia Momoyo
dc.contributor.authorPereira, Gustavo
dc.contributor.authorGoncalves, Luciana L.
dc.contributor.authorTorre, Aldo
dc.contributor.authorDiaz, Juan Manuel
dc.contributor.authorGadano, Adrian C.
dc.contributor.authorMattos, Angelo Z.
dc.contributor.authorMendes, Liliana S. C.
dc.contributor.authorAlvares-da-Silva, Mario R.
dc.contributor.authorBittencourt, Paulo L.
dc.contributor.authorBenitez, Carlos
dc.contributor.authorCouto, Claudia Alves
dc.contributor.authorMendizabal, Manuel
dc.contributor.authorToledo, Claudio L.
dc.contributor.authorMazo, Daniel F. C.
dc.contributor.authorBarradas, Mauricio Castillo
dc.contributor.authorRaposo, Eva M. Uson
dc.contributor.authorPadilla-Machaca, P. Martin
dc.contributor.authorMiranda, Adelina Zarela Lozano
dc.contributor.authorMale-Velazquez, Rene
dc.contributor.authorLyra, Andre Castro
dc.contributor.authorDavalos-Moscol, Milagros B.
dc.contributor.authorHernandez, Jose L. Perez
dc.contributor.authorXimenes, Rafael O.
dc.contributor.authorSilva, Giovanni Faria
dc.contributor.authorBeltran-Galvis, Oscar A.
dc.contributor.authorHuezo, Maria S. Gonzalez
dc.contributor.authorBessone, Fernando
dc.contributor.authorRocha, Tarciso D. S.
dc.contributor.authorFassio, Eduardo
dc.contributor.authorTerra, Carlos
dc.contributor.authorMarin, Juan I.
dc.contributor.authorCasas, Patricia Sierra
dc.contributor.authorde la Pena-Ramirez, Carlos
dc.contributor.authorParera, Ferran Aguilar
dc.contributor.authorFernandes, Flavia
dc.contributor.authorZago-Gomes, Maria da Penha
dc.contributor.authorMendez-Guerrero, Osvely
dc.contributor.authorMarciano, Sebastian
dc.contributor.authorMattos, Angelo A.
dc.contributor.authorOliveira, Joao C.
dc.contributor.authorGuerreiro, Gabriel T. S.
dc.contributor.authorCodes, Liana
dc.contributor.authorArrese, Marco
dc.contributor.authorNardelli, Mateus J.
dc.contributor.authorSilva, Marcelo O.
dc.contributor.authorPalma-Fernandez, Renato
dc.contributor.authorAlcantara, Camila
dc.contributor.authorGarrido, Cristina Sanchez
dc.contributor.authorTrebicka, Jonel
dc.contributor.authorGustot, Thierry
dc.contributor.authorFernandez, Javier
dc.contributor.authorClaria, Joan
dc.contributor.authorJalan, Rajiv
dc.contributor.authorAngeli, Paolo
dc.contributor.authorArroyo, Vicente
dc.contributor.authorMoreau, Richard
dc.contributor.authorACLARA Study Collaborators
dc.date.accessioned2025-01-20T20:06:02Z
dc.date.available2025-01-20T20:06:02Z
dc.date.issued2023
dc.description.abstractBACKGROUND & AIMS: Genetic ancestry or racial differences in health outcomes exist in diseases associated with systemic inflammation (eg, COVID-19). This study aimed to investigate the association of genetic ancestry and race with acute-on chronic liver failure (ACLF), which is characterized by acute systemic inflammation, multi-organ failure, and high risk of short-term death. METHODS: This prospective cohort study analyzed a comprehensive set of data, including genetic ancestry and race among several others, in 1274 patients with acutely decompensated cirrhosis who were nonelectively admitted to 44 hospitals from 7 Latin American countries. RESULTS: Three hundred ninety-five patients (31.0%) had ACLF of any grade at enrollment. Patients with ACLF had a higher median percentage of Native American genetic ancestry and lower median percentage of European ancestry than patients without ACLF (22.6% vs 12.9% and 53.4% vs 59.6%, respectively). The median percentage of African genetic ancestry was low among patients with ACLF and among those without ACLF. In terms of race, a higher percentage of patients with ACLF than patients without ACLF were Native American and a lower percentage of patients with ACLF than patients without ACLF were European American or African American. In multivariable analyses that adjusted for differences in sociodemographic and clinical characteristics, the odds ratio for ACLF at enrollment was 1.08 (95% CI, 1.03-1.13) with Native American genetic ancestry and 2.57 (95% CI, 1.84-3.58) for Native American race vs European American race CONCLUSIONS: In a large cohort of Latin American patients with acutely decompensated cirrhosis, increasing percentages of Native American ancestry and Native American race were factors independently associated with ACLF at enrollment.
dc.description.funderEuropean Foundation
dc.fuente.origenWOS
dc.identifier.doi10.1053/j.gastro.2023.05.033
dc.identifier.eissn1528-0012
dc.identifier.issn0016-5085
dc.identifier.urihttps://doi.org/10.1053/j.gastro.2023.05.033
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91717
dc.identifier.wosidWOS:001067083500001
dc.issue.numero3
dc.language.isoen
dc.pagina.final716
dc.pagina.inicio696
dc.revistaGastroenterology
dc.rightsacceso restringido
dc.subjectSystemic Inflammation
dc.subjectEthnicity
dc.subjectSociodemographic Data
dc.subjectLiver Transplantation
dc.subjectOutcomes
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenetic Ancestry, Race, and Severity of Acutely Decompensated Cirrhosis in Latin America
dc.typeartículo
dc.volumen165
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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