2D printing of functional wrinkled films by DOD technology: Evaluation of cytocompatibility, antibacterial and virucidal properties against corona virus model

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dc.article.number102777
dc.catalogadorpva
dc.contributor.authorRodríguez-Umanzor, Fernando E.
dc.contributor.authorAlarcón-Núñez, Matías N.
dc.contributor.authorSarabia Vallejos, Mauricio
dc.contributor.authorCohn-Inostroza, Nicolás A.
dc.contributor.authorMartínez-Campos, Enrique
dc.contributor.authorCue-López, Raquel
dc.contributor.authorRodríguez-Hernández, Juan
dc.contributor.authorTerraza Inostroza, Claudio
dc.contributor.authorGonzález-Henríquez, Carmen M.
dc.date.accessioned2025-05-20T16:28:54Z
dc.date.available2025-05-20T16:28:54Z
dc.date.issued2025
dc.description.abstractWrinkled polymeric films fabricated via Drop-on-Demand (DOD) inkjet printing offer a significant advancement in biomedical applications, combining antibacterial, virucidal, and cytocompatible properties (multifunctional biomaterials). This scalable and cost-effective method enables precise deposition of polymeric materials, creating customizable micro-wrinkled surfaces with high spatial resolution. The ability to deposit multiple materials simultaneously supports the development of gradient or multifunctional coatings tailored for biomedical needs. Functional monomer-based inks with a crosslinking agent were applied onto UV-ozonized polycarbonate substrates, enhancing hydrophilicity for uniform material deposition. Controlled UV exposure, vacuum drying, and plasma treatments produced homogeneous wrinkled patterns, which can be adapted for infection control and tissue engineering. Chemical analyses confirmed the polymerization and structural integrity of the films, while rheological studies validated the inks’ printability without satellite droplet formation. Biological evaluations revealed strong antibacterial effects against Staphylococcus aureus and Escherichia coli and complete inactivation of HCoV-229E, a human coronavirus model, in DMAEMA-based samples. Samples containing AAc and HEMA reduced infected cells by ~80 %; however, no significant differences were identified between smooth and wrinkled samples regarding virucidal capacity. These films also demonstrated robust cytocompatibility, making them a cost-effective, multifunctional solution for critical healthcare challenges. This represents one of the few materials that selectively combine antibacterial and virucidal properties while supporting cell proliferation, offering immense potential for advanced biomedical devices.
dc.format.extent12 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.apmt.2025.102777
dc.identifier.issn2352-9407
dc.identifier.urihttps://doi.org/10.1016/j.apmt.2025.102777
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104371
dc.information.autorucEscuela de Química; Terraza Inostroza, Claudio; 0000-0002-6326-8771; 1001668
dc.information.autorucInstituto de Física; Sarabia Vallejos, Mauricio; 0000-0001-5128-796X; 170370
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherElsevier Ltd.
dc.revistaApplied Materials Today
dc.rightsacceso restringido
dc.subjectWrinkled films
dc.subjectDrop-on-Demand (DOD) printing
dc.subjectMultifunctional polymeric surfaces
dc.subjectVirucidal surface
dc.subjectBiomedical engineering
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.title2D printing of functional wrinkled films by DOD technology: Evaluation of cytocompatibility, antibacterial and virucidal properties against corona virus model
dc.typeartículo
dc.volumen44
sipa.codpersvinculados1001668
sipa.codpersvinculados170370
sipa.trazabilidadORCID;2025-05-19
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