Presentation and Outcomes of Kawasaki Disease in Latin American Infants Younger Than 6 Months of Age: A Multinational Multicenter Study of the REKAMLATINA Network

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dc.contributor.authorMoreno, Elizabeth
dc.contributor.authorGarcia, S. Diana
dc.contributor.authorBainto, Emelia
dc.contributor.authorSalgado, Andrea P.
dc.contributor.authorParish, Austin
dc.contributor.authorRosellini, Benjamin D.
dc.contributor.authorUlloa-Gutierrez, Rolando
dc.contributor.authorGarrido-Garcia, Luis M.
dc.contributor.authorDuenas, Lourdes
dc.contributor.authorEstripeaut, Dora
dc.contributor.authorLuciani, Kathia
dc.contributor.authorRodriguez-Quiroz, Francisco J.
dc.contributor.authordel Aguila, Olguita
dc.contributor.authorCamacho-Moreno, German
dc.contributor.authorGomez, Virgen
dc.contributor.authorViviani, Tamara
dc.contributor.authorAlvarez-Olmos, Martha, I
dc.contributor.authorde Souza Marques, Heloisa Helena
dc.contributor.authorFaugier-Fuentes, Enrique
dc.contributor.authorSaltigeral-Simental, Patricia
dc.contributor.authorLopez-Medina, Eduardo
dc.contributor.authorMino-Leon, Greta
dc.contributor.authorBeltran, Sandra
dc.contributor.authorMartinez-Medina, Lucila
dc.contributor.authorPirez, Maria C.
dc.contributor.authorCofre, Fernanda
dc.contributor.authorTremoulet, Adriana H.
dc.date.accessioned2025-01-23T19:49:17Z
dc.date.available2025-01-23T19:49:17Z
dc.date.issued2020
dc.description.abstractObjective:To characterize the clinical presentation and outcomes of Kawasaki disease (KD) in infants Methods:We evaluated 36 infants <6 months old and 940 infants >= 6 months old diagnosed with KD in Latin America. We compared differences in laboratory data, clinical presentation, treatment response, and coronary artery outcomes between the two cohorts. Results:The majority (78.1%) of infants and children >= 6 months of age were initially diagnosed with KD, as compared to only 38.2% of infants <6 months. Clinical features of KD were more commonly observed in the older cohort: oral changes (92 vs. 75%,P= 0.0023), extremity changes (74.6 vs. 57.1%,P= 0.029), and cervical lymphadenopathy (67.6 vs. 37.1%,P= 0.0004). Whether treated in the first 10 days of illness or after the 10th day, infants <6 months were at greater risk of developing a coronary artery aneurysm compared to KD patients >= 6 months treated at the same point in the course of illness [ <= 10 days (53.8 vs. 9.4%,P= 0.00012); >10 days (50 vs. 7.4%,P= 0.043)]. Conclusion:Our data show that despite treatment in the first 10 days of illness, infants <6 months of age in Latin America have a higher risk of developing a coronary artery aneurysm. Delay in the diagnosis leads to larger coronary artery aneurysms disproportionately in these infants. Thus, suspicion for KD should be high in this vulnerable population.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fped.2020.00384
dc.identifier.issn2296-2360
dc.identifier.urihttps://doi.org/10.3389/fped.2020.00384
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100493
dc.identifier.wosidWOS:000556803800001
dc.language.isoen
dc.revistaFrontiers in pediatrics
dc.rightsacceso restringido
dc.subjectKawasaki disease
dc.subjectLatin America
dc.subjectinfants
dc.subjectcoronary artery abnormalities
dc.subjectdelayed diagnosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePresentation and Outcomes of Kawasaki Disease in Latin American Infants Younger Than 6 Months of Age: A Multinational Multicenter Study of the REKAMLATINA Network
dc.typeartículo
dc.volumen8
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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