Physiologic Consequences of Upper Airway Obstruction in Sleep Apnea

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dc.contributor.authorAzarbarzin, Ali
dc.contributor.authorLabarca, Gonzalo
dc.contributor.authorKwon, Younghoon
dc.contributor.authorWellman, Andrew
dc.date.accessioned2025-01-20T16:04:31Z
dc.date.available2025-01-20T16:04:31Z
dc.date.issued2024
dc.description.abstractOSA is diagnosed and managed by a metric called the apnea-hypopnea index (AHI). The AHI quantifies the number of respiratory events (apnea or hypopnea), disregarding important information on the characteristics and physiologic consequences of respiratory events, including degrees of ventilatory deficit and associated hypoxemia, cardiac autonomic response, and cortical activity. The oversimplification of the disorder by the AHI is considered one of the reasons for divergent findings on the associations of OSA and cardiovascular disease (CVD) in observational and randomized controlled trial studies. Prospective observational cohort studies have demonstrated strong associations of OSA with several cardiovascular diseases, and randomized controlled trials of CPAP intervention have not been able to detect a benefit of CPAP to reduce the risk of CVD. Over the last several years, novel methodologies have been proposed to better quantify the magnitude of OSA-related breathing disturbance and its physiologic consequences. As a result, stronger associations with cardiovascular and neurocognitive outcomes have been observed. In this review, we focus on the methods that capture polysomnographic heterogeneity of OSA. CHEST 2024; 166(5):1209-1217
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.chest.2024.05.028
dc.identifier.eissn1931-3543
dc.identifier.issn0012-3692
dc.identifier.urihttps://doi.org/10.1016/j.chest.2024.05.028
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89786
dc.identifier.wosidWOS:001354698700001
dc.issue.numero5
dc.language.isoen
dc.pagina.final1217
dc.pagina.inicio1209
dc.revistaChest
dc.rightsacceso restringido
dc.subjectKEY WORDS
dc.subjectAHI
dc.subjectcardiac autonomic response sleep apnea
dc.subjectcardiovascular
dc.subjecthypoxic burden
dc.subjectburden
dc.titlePhysiologic Consequences of Upper Airway Obstruction in Sleep Apnea
dc.typeartículo
dc.volumen166
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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