Effect of isoespintanol isolated from Oxandra cf. xylopioides against DNA damage of human lymphocytes

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dc.contributor.authorElena Marquez Fernandez, Maria
dc.contributor.authorCarolina Munoz Lassos, Diana
dc.contributor.authorBautista Lopez, Juan
dc.contributor.authorZapata, Karol
dc.contributor.authorPuertas Mejia, Miguel Angel
dc.contributor.authorLopez Alarcon, Camilo
dc.contributor.authorAlberto Rojano, Benjamin
dc.date.accessioned2024-01-10T12:38:31Z
dc.date.available2024-01-10T12:38:31Z
dc.date.issued2018
dc.description.abstractSynthetic antioxidants are used in the food and pharmaceutical industry, however, there is concern about their safety; this has prompted the search for new antioxidants that are effective, safe and act at low concentrations. The objective of this study is to evaluate the oxygen radical scavenging capacity and clastogenic effect of the Isoespintanol /2-isopropyl-3,6-dimethyl-5-methylphenol) in DNA of human lymphocyte compared with the BHA (Butylated hydroxyanisole). The oxygen radical scavenging ability was evaluated by methods ORAC(FL) and ORAC(PGR), genotoxicity was determined by comet assay and data analysis was performed using ANOVA and Duncan test. The results show that the oxygen radical scavenging capacity of the BHA is higher than Isoespintanol, however according to the reactivity concept proposed by Lopez-Alarcon and Lissi, the Isoespintanol it is more reactive than BHA. Furthermore, according to some studies, BHA presented adverse effects on the health of consumers. Comet assay results revealed that at concentrations between 3 and 1620 mu M the Isoespintanol don't show clastogenic effects on DNA. In conclusion, the antioxidant capacity for the BHA is higher than Isoespintanol, but considering reactivity concepts proposed by Lopez-Alarcon and Lissi, the Isoespintanol is faster to neutralize radicals that the BHA, furthermore, according to the National Institute of Health "BHA" is a human carcinogen.
dc.fechaingreso.objetodigital2024-06-19
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.issn1011-601X
dc.identifier.pubmedidMEDLINE:30150170
dc.identifier.wosidWOS:000445320400001
dc.information.autorucQuímica;Lopez-Alarcon C;S/I;1004308
dc.issue.numero5
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final1782
dc.pagina.inicio1777
dc.publisherUNIV KARACHI
dc.revistaPAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
dc.rightsacceso abierto
dc.subjectDNA damage
dc.subjectantioxidants
dc.subjectBHA
dc.subjectbiological products
dc.subjectCOMET ASSAY
dc.subjectANTIOXIDANT PROPERTIES
dc.subjectMICRONUCLEUS TEST
dc.subjectOXIDATIVE DAMAGE
dc.subjectQUERCETIN
dc.subjectSUPPLEMENTATION
dc.subjectFLUORESCEIN
dc.subjectINDUCTION
dc.subjectBEHAVIOR
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffect of isoespintanol isolated from Oxandra cf. xylopioides against DNA damage of human lymphocytes
dc.typeartículo
dc.volumen31
sipa.codpersvinculados1004308
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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