RELEASE OF H-3 NORADRENALINE FROM THE RAT OVIDUCT - CHANGES DURING ESTROUS-CYCLE AND BY PROGESTERONE INVITRO

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dc.contributor.authorCHIAPPE, P
dc.contributor.authorGALLEGUILLOS, X
dc.contributor.authorLARA, H
dc.contributor.authorFUENTEALBA, B
dc.contributor.authorFORRAY, I
dc.contributor.authorBELMAR, J
dc.date.accessioned2025-01-23T19:23:23Z
dc.date.available2025-01-23T19:23:23Z
dc.date.issued1990
dc.description.abstractRat oviduct noradrenergic innervation seems to be under the influence of hormonal modulation. Noradrenaline level is specifically affected, but other processes like the release of the neurotransmitter have not yet been studied. In this work the release of 3H-noradrenaline (3H-NA) during the estrous cycle and its modification by progesterone "in vitro", were studied. The basal 3H-NA outflow was unchanged during the estrous cycle. However, the induced release (K+, 80 mM) was maximal during estrous. After progesterone, induced 3H-NA release was inhibited at low concentrations (5 .mu.M); under higher concentrations (50 .mu.M) the effect persisted but basal outflow of radioactivity was increased. The inhibitory effect was potentiated by RU-486 (Progesterone blocker). Results suggest a modulatory role for the hormone and it could be related to interactions with nerve-ending membranes and not with classical nuclear receptors.
dc.fuente.origenWOS
dc.identifier.issn0001-6764
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99205
dc.identifier.wosidWOS:A1990DX51500003
dc.issue.numero2
dc.language.isoen
dc.pagina.final164
dc.pagina.inicio155
dc.revistaActa physiologica et pharmacologica latinoamericana
dc.rightsacceso restringido
dc.subject.ods05 Gender Equality
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa05 Igualdad de género
dc.subject.odspa03 Salud y bienestar
dc.titleRELEASE OF H-3 NORADRENALINE FROM THE RAT OVIDUCT - CHANGES DURING ESTROUS-CYCLE AND BY PROGESTERONE INVITRO
dc.typeartículo
dc.volumen40
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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