3D Whole‐Heart Joint T1/T1ρ Mapping and Water‐Fat Imaging on a Clinical 0.55‐T Low‐Field Scanner

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dc.article.numbere70195
dc.catalogadorvzp
dc.contributor.authorCrabb, Michael G.
dc.contributor.authorKunze, Karl P.
dc.contributor.authorCastillo Passi, Carlos
dc.contributor.authorSi, Dongyue
dc.contributor.authorLittlewood, Simon J.
dc.contributor.authorPrieto Vásquez, Claudia
dc.contributor.authorBotnar, Rene Michael
dc.date.accessioned2026-01-12T15:49:52Z
dc.date.available2026-01-12T15:49:52Z
dc.date.issued2026
dc.description.abstractMyocardial maps are conventionally acquired in 2D breath-hold single-parameter scans that are slow and have limited heart coverage. To overcome limitations associated with 2D breath-hold mapping sequences, we develop a novel free-breathing 3D joint T₁ / T₁ρ mapping sequence with Dixon encoding to provide co-registered 3D T₁ and T₁ρ maps and water-fat volumes with isotropic spatial resolution in a single scan for comprehensive contrast-agent free myocardial tissue characterization and visualization of the whole-heart anatomy on a clinical 0.55-T MR scanner. The proposed sequence acquires four interleaved 3D volumes with preparation modules to provide T₁ and T₁ρ encoding, with data acquired with a two-echo Dixon readout and 2D image navigators to enable 100% respiratory scan efficiency. Images were reconstructed with nonrigid respiratory motion-corrected iterative SENSE with multi-dimensional low-rank patch-based denoising, and maps generated by matching with simulated dictionaries. The proposed sequence was tested in phantoms, 11 healthy subjects and 1 patient, and compared with conventional techniques. For phantoms, the proposed 3D T₁ and T₁ρ measurements showed good correlation with 2D spin-echo reference measurements. For healthy subjects, septal myocardial tissue mapping values were T₁ = 743 ± 19 ms and T₁ρ = 46.9 ± 2.7 ms for the proposed sequence, against T₁ = 681 ± 23 ms and T₁ρ = 57.9 ± 3.6 ms for 2D modified Look-Locker inversion recovery and 2D T₁ρ, respectively. Promising results were obtained when the proposed mapping was compared to 2D late-gadolinium enhancement imaging in a patient. The proposed approach enables simultaneous 3D whole-heart joint T₁ / T₁ρ mapping and water-fat imaging at 0.55 T in a single scan of ≈ 11 min, demonstrating good agreement with conventional techniques in phantoms and healthy subjects, and promising results in a patient.
dc.fechaingreso.objetodigital2026-01-12
dc.format.extent15 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1002/nbm.70195
dc.identifier.eissn1099-1492
dc.identifier.issn0952-3480
dc.identifier.urihttps://doi.org/10.1002/nbm.70195
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107639
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Castillo Passi, Carlos Andres; 0000-0001-6227-0477; 204150
dc.information.autorucEscuela de Ingeniería; Prieto Vásquez, Claudia Del Carmen; 0000-0003-4602-2523; 14195
dc.information.autorucInstituto de Ingeniería Biológica y Médica; Botnar, Rene Michael; 0000-0003-2811-2509; 1015313
dc.issue.numero2
dc.nota.accesocontenido completo
dc.revistaNMR in Biomedicine
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectCardiac MRI
dc.subjectLow- field
dc.subjectMyocardial tissue characterisation
dc.subject3D multiparametric MRI
dc.subjectT1 mapping 
dc.subjectT₁ρ mapping
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.title3D Whole‐Heart Joint T1/T1ρ Mapping and Water‐Fat Imaging on a Clinical 0.55‐T Low‐Field Scanner
dc.typeartículo
dc.volumen39
sipa.codpersvinculados204150
sipa.codpersvinculados14195
sipa.codpersvinculados1015313
sipa.trazabilidadORCID;2026-01-05
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