Fertilisation involving ageing gametes, major birth defects, and Down's syndrome

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dc.contributor.authorSimpson, JL
dc.contributor.authorGray, R
dc.contributor.authorPerez, A
dc.contributor.authorMena, P
dc.contributor.authorQueenan, J
dc.contributor.authorBarbato, M
dc.contributor.authorPardo, F
dc.contributor.authorKambic, R
dc.contributor.authorJennings, V
dc.date.accessioned2025-01-21T01:30:25Z
dc.date.available2025-01-21T01:30:25Z
dc.date.issued2002
dc.description.abstractFor many years, ageing of gametes as a result of prolonged retention In the female reproductive tract before fertilisation has been circumstantially associated with major birth defects. To assess this association, we studied pregnant women who had recorded the timing, with regard to presumed ovulation, of the coital event leading to conception. We found major anomalies In 11 l of 400 Infants born to women with optimally timed conceptions (on the day of or 1 day before ovulation), compared with 14 (2.5%) of 538 Infants of women with non-optimally timed conceptions (odds ratio 0.94, 95% CI 0.43-2.06). The numbers of Infants with Down's syndrome were two l of 400, and four (0.7%) of 538, respectively (1.48, 0.27-8.06). There is no association between ageing gametes and major birth defects, Including Down's syndrome.
dc.fuente.origenWOS
dc.identifier.issn0140-6736
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96750
dc.identifier.wosidWOS:000175593300014
dc.issue.numero9318
dc.language.isoen
dc.pagina.final1671
dc.pagina.inicio1670
dc.revistaLancet
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFertilisation involving ageing gametes, major birth defects, and Down's syndrome
dc.typeartículo
dc.volumen359
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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