Synergic vascular photodynamic activity by methylene blue-curcumin supramolecular assembly

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dc.contributor.authorSilva, Rodrigo C.
dc.contributor.authorBuzza, Hilde H.
dc.contributor.authorDucas, Eli S. A.
dc.contributor.authorOliveira, Kleber T.
dc.contributor.authorBagnato, Vanderlei S.
dc.contributor.authorSouza, Guilherme R. L.
dc.contributor.authorAlmeida, Luciane M.
dc.contributor.authorGoncalves, Pablo J.
dc.date.accessioned2025-01-20T17:35:44Z
dc.date.available2025-01-20T17:35:44Z
dc.date.issued2023
dc.description.abstractA supramolecular assembly was obtained by combining methylene blue (MB) with a natural plant extract, curcumin (Curc), in a stoichiometric ratio of 1:4 in aqueous solution (90% PBS + 10% ethanol) at room temperature. The MB-Curc supramolecular assembly was evidenced by absorption and fluorescence spectroscopies, and the stoichiometry and bonding constant were obtained using Cielens model. Its stability and photostability were evaluated by chromatographic analysis and UV-Vis absorption. The MB-Curc avoids the aggregation of both isolated compounds and efficiently produces singlet oxygen (& phi;& UDelta;= 0.52 & PLUSMN; 0.03). Its potential for photodynamic antiangiogenic treatments was evaluated through the vascular effect observed in chicken chorioallantoic membrane (CAM) assay. The results showed intense damage in CAM vascular network by MB-Curc after irradiation, which is higher than the effect of isolated compounds, indicating a synergistic vascular effect. This combination can be essential to prevent cancer revascularization after photodynamic application and improve the efficacy of this approach. The characteristics exhibited by MB-Curc make it a potential candidate for use in cancer treatments through photodynamic antiangiogenic therapy.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.saa.2023.123281
dc.identifier.eissn1873-3557
dc.identifier.issn1386-1425
dc.identifier.urihttps://doi.org/10.1016/j.saa.2023.123281
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91677
dc.identifier.wosidWOS:001069589700001
dc.language.isoen
dc.revistaSpectrochimica acta part a-molecular and biomolecular spectroscopy
dc.rightsacceso restringido
dc.subjectVascular PDT
dc.subjectPhotodynamic therapy
dc.subjectPhotodynamic antiangiogenic therapy
dc.subjectSinglet oxygen
dc.subjectSupramolecular combined photosensitizers
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSynergic vascular photodynamic activity by methylene blue-curcumin supramolecular assembly
dc.typeartículo
dc.volumen303
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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