ENDOSCOPIC INTRASPHINCTERIC INJECTION OF BOTULINUM TOXIN FOR THE TREATMENT OF ACHALASIA

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dc.contributor.authorROLLAN, A
dc.contributor.authorGONZALEZ, R
dc.contributor.authorCARVAJAL, S
dc.contributor.authorCHIANALE, J
dc.date.accessioned2024-01-10T13:12:45Z
dc.date.available2024-01-10T13:12:45Z
dc.date.issued1995
dc.description.abstractThree patients with achalasia were treated with endoscopic injection of botulinum toxin (BoTx). BoTx (80 U) was injected via a sclerotherapy needle into the lower esophageal sphincter (LES). One patient complained of transient heartburn that resolved after omeprazole treatment. Two patients reported sustained symptomatic improvement. They were able to eat normally 48 h after treatment and have remained symptom free for 5 and 6.5 months, respectively. In these patients, esophageal manometry 4 months after treatment showed a marked reduction of resting LES pressure and the appearance of a previously absent LES relaxation after swallowing. The third patient had only a transient clinical improvement, with occasional dysphagia beginning 3 months after treatment. All patients showed unchanged aperistalsis of the esophageal body. Its less invasive nature compared with other therapeutic alternatives may give BoTX injection a role in the treatment of some patients with achalasia.
dc.fechaingreso.objetodigital2024-04-30
dc.format.extent3 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/00004836-199504000-00004
dc.identifier.issn0192-0790
dc.identifier.pubmedidMEDLINE:7797823
dc.identifier.urihttps://doi.org/10.1097/00004836-199504000-00004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78225
dc.identifier.wosidWOS:A1995QT04600004
dc.information.autorucMedicina;Chianale J;S/I;99780
dc.information.autorucMedicina;Rollan A;S/I;100118
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final191
dc.pagina.inicio189
dc.publisherLIPPINCOTT-RAVEN PUBL
dc.revistaJOURNAL OF CLINICAL GASTROENTEROLOGY
dc.rightsacceso restringido
dc.subjectACHALASIA
dc.subjectESOPHAGUS
dc.subjectBOTULINUM TOXIN
dc.subjectENDOSCOPIC THERAPY
dc.subjectLOWER ESOPHAGEAL SPHINCTER
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleENDOSCOPIC INTRASPHINCTERIC INJECTION OF BOTULINUM TOXIN FOR THE TREATMENT OF ACHALASIA
dc.typeartículo
dc.volumen20
sipa.codpersvinculados99780
sipa.codpersvinculados100118
sipa.indexWOS
sipa.trazabilidadCarga SIPA;09-01-2024
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