Clinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype

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dc.contributor.authorMartin-Nares, Eduardo
dc.contributor.authorFederico Baenas, Diego
dc.contributor.authorCuellar Gutierrez, Maria Carolina
dc.contributor.authorHernandez-Molina, Gabriela
dc.contributor.authorChristian Ortiz, Alberto
dc.contributor.authorNeira, Oscar
dc.contributor.authorGutierrez, Miguel A.
dc.contributor.authorCalvo, Romina
dc.contributor.authorJose Saad, Emanuel
dc.contributor.authorElgueta Pinochet, Sergio
dc.contributor.authorGallo, Jesica
dc.contributor.authorHerrera Moya, Alejandra
dc.contributor.authorMansilla Aravena, Bellanides Agustina
dc.contributor.authorCrespo Espindola, Maria Elena
dc.contributor.authorCairoli, Ernesto
dc.contributor.authorMaria Bertoli, Ana
dc.contributor.authorCordoba, Mercedes
dc.contributor.authorWurmann Kiblisky, Pamela
dc.contributor.authorBasualdo Arancibia, Washington Javier
dc.contributor.authorBadilla Pineiro, Maria Natalia
dc.contributor.authorAndrea Gobbi, Carla
dc.contributor.authorAriel Berbotto, Guillermo
dc.contributor.authorPisoni, Cecilia N.
dc.contributor.authorJuarez, Vicente
dc.contributor.authorAna Cosatti, Micaela
dc.contributor.authorAste, Nora Maria
dc.contributor.authorAiroldi, Carla
dc.contributor.authorLlanos, Carolina
dc.contributor.authorVergara Melian, Cristian Fabian
dc.contributor.authorErlij Opazo, Daniel
dc.contributor.authorGoecke, Annelise
dc.contributor.authorPastenes Montano, Paula Andrea
dc.contributor.authorTate, Patricio
dc.contributor.authorPablo Pirola, Juan
dc.contributor.authorStange Nunez, Lilith
dc.contributor.authorBurgos, Paula, I
dc.contributor.authorMezzano Robinson, Maria Veronica
dc.contributor.authorMichalland, Susana H.
dc.contributor.authorSilva Labra, Francisco
dc.contributor.authorLabarca Solar, Cristian Humberto
dc.contributor.authorVeronica Lencina, Maria
dc.contributor.authorIzquierdo Loaiza, Jorge Hernan
dc.contributor.authorDel Castillo Gil, David Julian
dc.contributor.authorCaeiro, Francisco
dc.contributor.authorPaira, Sergio
dc.date.accessioned2025-01-20T21:02:33Z
dc.date.available2025-01-20T21:02:33Z
dc.date.issued2022
dc.description.abstractBackground/Objective Data on IgG4-related disease (IgG4-RD) come almost exclusively from cohorts from Asia, Europe, and North America. We conducted this study to describe the clinical presentation, phenotype distribution, and association with sex, ethnicity, and serological markers in a large cohort of Latin American patients with IgG4-RD. Methods We performed a multicenter medical records review study including 184 Latin American IgG4-RD patients. We assigned patients to clinical phenotypes: group 1 (pancreato-hepato-biliary), group 2 (retroperitoneal/aortic), group 3 (head and neck-limited), group 4 (Mikulicz/systemic), and group 5 (undefined). We focused the analysis on how sex, ethnicity, and clinical phenotype may influence the clinical and serological presentation. Results The mean age was 50.8 +/- 15 years. Men and women were equally affected (52.2% vs 48.8%). Fifty-four patients (29.3%) were assigned to group 1, 21 (11.4%) to group 2, 57 (30.9%) to group 3, 32 (17.4%) to group 4, and 20 (10.8%) to group 5. Male sex was associated with biliary tract (odds ratio [OR], 3.4; 95% confidence interval [CI], 1.36-8.26), kidney (OR, 3.4; 95% CI, 1.28-9.25), and retroperitoneal involvement (OR, 5.3; 95% CI, 1.45-20). Amerindian patients presented more frequently with atopy history and gallbladder involvement. Group 3 had a female predominance. Conclusions Latin American patients with IgG4-RD were younger, and men and women were equally affected compared with White and Asian cohorts. They belonged more commonly to group 1 and group 3. Retroperitoneal and aortic involvement was infrequent. Clinical and serological features differed according to sex, ethnicity, and clinical phenotype.
dc.fuente.origenWOS
dc.identifier.doi10.1097/RHU.0000000000001858
dc.identifier.eissn1536-7355
dc.identifier.issn1076-1608
dc.identifier.urihttps://doi.org/10.1097/RHU.0000000000001858
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93051
dc.identifier.wosidWOS:000844826000001
dc.issue.numero6
dc.language.isoen
dc.pagina.final292
dc.pagina.inicio285
dc.revistaJcr-journal of clinical rheumatology
dc.rightsacceso restringido
dc.subjectphenotype
dc.subjectIgG4-related disease
dc.subjectLatin American
dc.subjectretroperitoneal fibrosis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClinical and Serological Features in Latin American IgG4-Related Disease Patients Differ According to Sex, Ethnicity, and Clinical Phenotype
dc.typeartículo
dc.volumen28
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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