Plasma insulin-like growth factor-II (IGF-II) and IGF-II/IGF-I ratio in a chilean case of Doege-Potter Syndrome

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dc.contributor.authorTobar, Hugo E.
dc.contributor.authorIbaceta, Rodrigo
dc.contributor.authorFigueroa, Ana-Maria
dc.contributor.authorQuinones, Veronica
dc.contributor.authorIniguez, German
dc.contributor.authorSalman, Patricio
dc.contributor.authorSerrano, Valentina
dc.contributor.authorSalinas, Lorena
dc.contributor.authorSantos, Jose Luis
dc.date.accessioned2025-01-20T17:13:58Z
dc.date.available2025-01-20T17:13:58Z
dc.date.issued2023
dc.description.abstractIntroduction: Doege-Potter syndrome is a rare clinical entity characterized by recurrent hypoglycemic events caused by non-pancreatic tumors secreting an incompletely processed high-molecular-weight form of Insulin-like Growth factor-II (IGF-II). Aim: To report IGF-II and IGF-I circulating levels in a Chilean case of Doege-Potter syndrome and control individuals, and to identify the high-molecular-weight form of IGF-II. Methods: We measured IGF-II and IGF-I plasma levels using enzyme-linked immunoassays (ELISA) in the patient and ten controls. We identified the high-molecular-weight form of IGF-II performed by Western blot. Results: The plasma concentration of IGF-II in the patient was 868.9 ng/mL, which is only slightly > 80th percentile of controls (681,4 +/- 212,8 ng/mL; mean +/- standard deviation). In contrast, IGF-I plasma concentration in the patient was 17.6 ng/mL, which is notoriously lower than the corresponding levels in controls (109.1 +/- 19.1 ng/mL). The IGF-II/IGF-I ratio in the patient was 49.4 (normal value < 10), which is 7.8 times higher compared to the average ratio of controls (6.3 +/- 1.5). The high-molecular form of IGF-II presence in samples was confirmed through Western blot. Conclusions: The plasma IGF-II/IGF-I ratio better indicates the Doege-Potter syndrome's metabolic impairment than isolated measurements of circulating IGF-II or IGF-I levels.
dc.description.funderDepartment of Nutrition, Diabetes and Metabolism
dc.fuente.origenWOS
dc.identifier.eissn0717-6163
dc.identifier.issn0034-9887
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91275
dc.identifier.wosidWOS:001223730900015
dc.issue.numero10
dc.language.isoen
dc.pagina.final1410
dc.pagina.inicio1406
dc.revistaRevista medica de chile
dc.rightsacceso restringido
dc.subjectHypoglycemia
dc.subjectInsulin-Like Growth Factor I
dc.subjectReceptor, IGF Type 2
dc.subjectSolitary Fibrous Tumor, Pleural
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlasma insulin-like growth factor-II (IGF-II) and IGF-II/IGF-I ratio in a chilean case of Doege-Potter Syndrome
dc.typeartículo
dc.volumen151
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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