Characterization of the anti-inflammatory capacity of IL-10-Producing neutrophils in response to streptococcus pneumoniae infection

Simple item page
dc.article.number638917
dc.catalogadorpva
dc.contributor.authorGonzález Carreño, Liliana Andrea
dc.contributor.authorMelo González, Felipe Andrés
dc.contributor.authorSebastián Quijada, Valentina Pilar
dc.contributor.authorVallejos Galvez, Omar Patricio
dc.contributor.authorNoguera Mijares, Loreani Paola
dc.contributor.authorSuazo Galvez, Isidora del Carmen
dc.contributor.authorSchultz Lombardic, Bárbara M.
dc.contributor.authorManosalva, Andres H.
dc.contributor.authorPeñaloza, Hernán F.
dc.contributor.authorSoto Ramírez, Jorge Andres
dc.contributor.authorParker, Dane
dc.contributor.authorRiedel, Claudia A.
dc.contributor.authorGonzález Muñoz, Pablo Alberto
dc.contributor.authorKalergis Parra, Alexis Mikes
dc.contributor.authorBueno Ramírez, Susan
dc.date.accessioned2024-01-23T16:24:40Z
dc.date.available2024-01-23T16:24:40Z
dc.date.issued2021
dc.description.abstractNeutrophils are immune cells classically defined as pro-inflammatory effector cells. However, current accumulated evidence indicates that neutrophils have more versatile immune-modulating properties. During acute lung infection with Streptococcus pneumoniae in mice, interleukin-10 (IL-10) production is required to temper an excessive lung injury and to improve survival, yet the cellular source of IL-10 and the immunomodulatory role of neutrophils during S. pneumoniae infection remain unknown. Here we show that neutrophils are the main myeloid cells that produce IL-10 in the lungs during the first 48 h of infection. Importantly, in vitro assays with bone-marrow derived neutrophils confirmed that IL-10 can be induced by these cells by the direct recognition of pneumococcal antigens. In vivo, we identified the recruitment of two neutrophil subpopulations in the lungs following infection, which exhibited clear morphological differences and a distinctive profile of IL-10 production at 48 h post-infection. Furthermore, adoptive transfer of neutrophils from WT mice into IL-10 knockout mice (Il10(-/-) ) fully restored IL-10 production in the lungs and reduced lung histopathology. These results suggest that IL-10 production by neutrophils induced by S. pneumoniae limits lung injury and is important to mediate an effective immune response required for host survival.
dc.description.funderFondo Nacional de Ciencia y Tecnologia de Chile (FONDECYT)
dc.description.funderANID-Millenium Science Initiative Program: Millenium Institute on Immunology and Immunotherapy
dc.description.funderAgencia Nacional de Investigacion y Desarrollo
dc.description.funderINNOVA CORFO program of Chilean Ministry of Economy
dc.description.funderInnovation Fund for Competitiveness FIC-R 2017 from the NIH
dc.description.funderPilot Project Program in Hemostasis and Vascular Biology (P3HVB), University of Pittsburgh Vascular Medicine Institute
dc.description.funderHemophilia Center of Western Pennsylvania
dc.description.funderInstitute for Transfusion Medicine
dc.fechaingreso.objetodigital2024-01-23
dc.fuente.origenWOS
dc.identifier.doi10.3389/fimmu.2021.638917
dc.identifier.issn1664-3224
dc.identifier.pubmedidMEDLINE:33995357
dc.identifier.urihttps://doi.org/10.3389/fimmu.2021.638917
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80920
dc.identifier.wosidWOS:000649317700001
dc.information.autorucFacultad de Ciencias Biológicas; González Carreño, Liliana Andrea; S/I; 250114
dc.information.autorucFacultad de Ciencias Biológicas; Melo González, Felipe Andrés; 0000-0002-3711-2407; 149763
dc.information.autorucFacultad de Ciencias Biológicas; Sebastián Quijada, Valentina Pilar; S/I; 171925
dc.information.autorucFacultad de Ciencias Biológicas; Vallejos Galvez, Omar Patricio; S/I; 215421
dc.information.autorucFacultad de Ciencias Biológicas; Noguera Mijares, Loreani Paola; S/I; 225123
dc.information.autorucFacultad de Ciencias Biológicas; Suazo Galvez, Isidora del Carmen; 0000-0001-8274-7471; 215403
dc.information.autorucFacultad de Ciencias Biológicas; Schultz Lombardic, Bárbara M.; 0000-0002-6201-6978; 186964
dc.information.autorucFacultad de Ciencias Biológicas; Soto Ramírez, Jorge Andres; 0000-0003-0335-9759; 237269
dc.information.autorucFacultad de Ciencias Biológicas; González Muñoz, Pablo Alberto; 0000-0001-7709-6870; 15616
dc.information.autorucFacultad de Ciencias Biológicas; Kalergis Parra, Alexis Mikes; 0000-0001-7622-5263; 90610
dc.information.autorucFacultad de Ciencias Biológicas; Bueno Ramírez, Susan; 0000-0002-7551-8088; 113541
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final16
dc.pagina.inicio1
dc.publisherFRONTIERS MEDIA SA
dc.revistaFrontiers in Immunologyes_ES
dc.rightsacceso abierto
dc.rights.licenseCreative Commons Attribution License (CC BY)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectPneumoniaes_ES
dc.subjectStreptococcus pneumoniaees_ES
dc.subjectInterleukin-10es_ES
dc.subjectIL-10-producing neutrophilses_ES
dc.subjectAdoptive neutrophil transferes_ES
dc.subjectIMMUNE-RESPONSEes_ES
dc.subjectIL-10es_ES
dc.subjectCHILDRENes_ES
dc.subjectHOSTes_ES
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCharacterization of the anti-inflammatory capacity of IL-10-Producing neutrophils in response to streptococcus pneumoniae infectiones_ES
dc.typeartículo
dc.volumen12
sipa.codpersvinculados250114
sipa.codpersvinculados149763
sipa.codpersvinculados171925
sipa.codpersvinculados215421
sipa.codpersvinculados225123
sipa.codpersvinculados215403
sipa.codpersvinculados186964
sipa.codpersvinculados237269
sipa.codpersvinculados15616
sipa.codpersvinculados90610
sipa.codpersvinculados113541
sipa.trazabilidadWOS;05-06-2021
sipa.trazabilidadORCID;2024-01-15
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Characterization of the Anti-Inflammatory.pdf
Size:
13.19 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Artículos de revistas