Stable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils

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dc.contributor.authorAlvarez, A
dc.contributor.authorAlarcón, R
dc.contributor.authorOpazo, C
dc.contributor.authorCampos, EO
dc.contributor.authorMuñoz, FJ
dc.contributor.authorCalderón, FH
dc.contributor.authorDajas, F
dc.contributor.authorGentry, MK
dc.contributor.authorDoctor, BP
dc.contributor.authorDe Mello, FG
dc.contributor.authorInestrosa, NC
dc.date.accessioned2025-01-21T01:32:43Z
dc.date.available2025-01-21T01:32:43Z
dc.date.issued1998
dc.description.abstractBrain acetylcholinesterase (AChE) forms stable complexes with amyloid-beta peptide (A beta) during its assembly into filaments, in agreement with its colocalization with the A beta deposits of Alzheimer's brain. The association of the enzyme with nascent A beta aggregates occurs as early as after 30 min of incubation. Analysis of the catalytic activity of the AChE incorporated into these complexes shows an anomalous behavior reminiscent of the AChE associated with senile plaques, which includes a resistance to low pH, high substrate concentrations, and lower sensitivity to AChE inhibitors. Furthermore, the toxicity of the AChE-amyloid complexes is higher than that of the A beta aggregates alone. Thus, in addition to its possible role as a heterogeneous nucleator during amyloid formation, AChE, by forming such stable complexes, may increase the neurotoxicity of A beta fibrils and thus may determine the selective neuronal loss observed in Alzheimer's brain.
dc.fuente.origenWOS
dc.identifier.issn0270-6474
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97310
dc.identifier.wosidWOS:000073173100011
dc.issue.numero9
dc.language.isoen
dc.pagina.final3223
dc.pagina.inicio3213
dc.revistaJournal of neuroscience
dc.rightsacceso restringido
dc.subjectAChE
dc.subjectA beta-amyloid fibrils
dc.subjectAChE-A beta-amyloid fibril complexes
dc.subjectamyloid formation
dc.subjectAlzheimer's disease
dc.subjectneurotoxicity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleStable complexes involving acetylcholinesterase and amyloid-β peptide change the biochemical properties of the enzyme and increase the neurotoxicity of Alzheimer's fibrils
dc.typeartículo
dc.volumen18
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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