Usefulness of Interferon-gamma Release Assays in the Diagnosis of Erythema Induratum

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dc.contributor.authorVera Kellet, Cristián Andrés
dc.contributor.authorPeters, Laurenna
dc.contributor.authorElwood, Kevin
dc.contributor.authorDutz, Jan P.
dc.date.accessioned2024-01-10T13:44:06Z
dc.date.available2024-01-10T13:44:06Z
dc.date.issued2011
dc.description.abstractBackground: Erythema induratum (EI) manifests as tender indurated nodules on the lower legs. It may be associated with concomitant active tuberculosis (TB) and is considered a hypersensitivity reaction to mycobacterial antigens. However, the results of Mycobacterium cultures are rarely positive, and the tuberculin skin test is of limited usefulness in populations exposed to bacille Calmette-Guerin (BCG). Interferon-gamma release assays (IGRAs) are alternatives to the tuberculin skin test and have high specificity. We explored the use of IGRAs as an adjunct in the diagnosis of EI. We describe 5 patients with positive tuberculin skin test results and a history of vaccination against BCG or TB in whom IGRAs supported the diagnosis of EI. Observations: All patients were initially seen with tender nodules on the lower legs and a history of BCG vaccination or TB. Tuberculin skin test results were positive, and chest radiographic results were normal. The results of Mycobacterium cultures were negative in all patients, and biopsy specimens were compatible with EI. Interferon-gamma release assays were performed in all patients and supported initiation of anti-TB treatment in 4 of 5 patients. Conclusion: Interferon-gamma release assays may have value as an adjunct in the diagnosis of EI, particularly in the setting of prior BCG exposure. Conclusion: Interferon-gamma release assays may have value as an adjunct in the diagnosis of EI, particularly in the setting of prior BCG exposure.
dc.description.funderChile Bicentennial Scholarship (Becas Chile)
dc.description.funderPontificia Universidad Catolica de Chile
dc.description.funderChild and Family Research Institute
dc.fechaingreso.objetodigital02-04-2024
dc.format.extent4 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1001/archdermatol.2011.183
dc.identifier.eissn1538-3652
dc.identifier.issn0003-987X
dc.identifier.pubmedidMEDLINE:21844454
dc.identifier.urihttps://doi.org/10.1001/archdermatol.2011.183
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78839
dc.identifier.wosidWOS:000293856400012
dc.information.autorucMedicina;Vera C ;S/I;9379
dc.issue.numero8
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final952
dc.pagina.inicio949
dc.publisherAMER MEDICAL ASSOC
dc.revistaARCHIVES OF DERMATOLOGY
dc.rightsacceso restringido
dc.subjectPOLYMERASE-CHAIN-REACTION
dc.subjectMYCOBACTERIUM-TUBERCULOSIS DNA
dc.subjectCUTANEOUS TUBERCULOSIS
dc.subjectCLINICAL-EVALUATION
dc.subjectINFECTION
dc.subjectMETAANALYSIS
dc.subjectBAZIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleUsefulness of Interferon-gamma Release Assays in the Diagnosis of Erythema Induratum
dc.typeartículo
dc.volumen147
sipa.codpersvinculados9379
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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