Alcohol-Associated Liver Disease: Integrated Management With Alcohol Use Disorder

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dc.article.number2980
dc.contributor.authorArab, Juan P.
dc.contributor.authorAddolorato, Giovanni
dc.contributor.authorMathurin, Philippe
dc.contributor.authorThursz, Mark R.
dc.date.accessioned2025-05-01T10:31:10Z
dc.date.available2025-05-01T10:31:10Z
dc.date.issued2023
dc.description.abstractAlcohol-associated liver disease (ALD) is the most common cause of cirrhosis and liver-related mortality in many re-gions worldwide. Around 75% of patients with cirrhosis are unaware of their disease until they are referred to the emergency department. An innovative, noninvasive screening approach is required for an earlier diagnosis of liver fibrosis. In patients with ALD the physician is inevi-tably dealing with 2 major disorders: the liver disease it-self and the alcohol use disorder (AUD). Focus only on the liver disease will inevitably lead to failure because tran-sient improvements in liver function are rapidly over-turned if the patient returns to alcohol consumption. For this reason, integrated models of care provided by hep-atologists and addiction specialists are an effective approach, which are, however, not widely available. There are multiple pharmacologic and non-pharmacologic ther-apies for AUD. Progress has recently been made in the management of patients with severe AH who have improved survival through better understanding of the concept of response to medical treatment, improved sur-vival prediction, and the advent of early liver trans-plantation. The emerging concept is that listing for transplantation a patient with severe ALD could lead to adjusting the duration of abstinence according to the severity and evolution of liver dysfunction and the pa-tient's addictive profile.
dc.description.funderANID Fondecyt Iniciacion
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.cgh.2023.02.017
dc.identifier.eisbn978-1-5106-5352-8
dc.identifier.eissn1542-7714
dc.identifier.isbn978-1-5106-5351-1
dc.identifier.issn1542-3565
dc.identifier.pubmedid40243597
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:105001560634
dc.identifier.urihttps://doi.org/10.1016/j.cgh.2023.02.017
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103720
dc.identifier.wosidWOS:001034413300001
dc.information.autorucEscuela de Medicina; Arab Verdugo Juan Pablo; 0000-0002-8561-396X; 132745
dc.issue.numero8
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final2134
dc.pagina.inicio2124
dc.relation.ispartofInternational Conference on Intelligent User Interfaces (30a. : 2025)
dc.revistaCLINICAL GASTROENTEROLOGY AND HEPATOLOGY
dc.rightsregistro bibliográfico
dc.subjectAlcohol
dc.subjectCirrhosis
dc.subjectAlcohol-Associated Hepatitis
dc.subjectAlcohol Use Disorder
dc.subjectFatty Liver Disease
dc.subject.ddc510
dc.subject.deweyMatemática física y químicaes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAlcohol-Associated Liver Disease: Integrated Management With Alcohol Use Disorder
dc.typeartículo
dc.volumen21
sipa.codpersvinculados132745
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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