Weight Loss and Metabolic Improvement in Morbidly Obese Subjects Implanted for 1 Year With an Endoscopic Duodenal-Jejunal Bypass Liner

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dc.contributor.authorEscalona, Alex
dc.contributor.authorPimentel, Fernando
dc.contributor.authorSharp, Allan
dc.contributor.authorBecerra, Pablo
dc.contributor.authorSlako, Milenko
dc.contributor.authorTuriel, Dannae
dc.contributor.authorMunoz, Rodrigo
dc.contributor.authorBambs, Claudia
dc.contributor.authorGuzman, Sergio
dc.contributor.authorIbanez, Luis
dc.contributor.authorGersin, Keith
dc.date.accessioned2024-01-10T13:09:57Z
dc.date.available2024-01-10T13:09:57Z
dc.date.issued2012
dc.description.abstractObjective: To evaluate safety, weight loss, and cardiometabolic changes in obese subjects implanted with the duodenal-jejunal bypass liner (DJBL) for 1 year.
dc.description.abstractBackground: The DJBL is an endoscopic implant that mimics the duodenal-jejunal bypass component of the Roux-en-Y gastric bypass. Previous reports have shown significant weight loss and improvement in type 2 diabetes for up to 6 months.
dc.description.abstractMethods: Morbidly obese subjects were enrolled in a single arm, open label, prospective trial and implanted with the DJBL. Primary endpoints included safety and weight change from baseline to week 52. Secondary endpoints included changes in waist circumference, blood pressure, lipids, glycemic control, and metabolic syndrome.
dc.description.abstractResults: The DJBL was implanted endoscopically in 39 of 42 subjects (age: 36 +/- 10 years; 80% female; weight: 109 +/- 18 kg; BMI: 43.7 +/- 5.9 kg/m(2)); 24 completed 52 weeks of follow-up. Three subjects could not be implanted due to short duodenal bulb. Implantation time was 24 +/- 2 minutes. There were no procedure-related complications and there were 15 early endoscopic removals. In the 52-week completer population, total body weight change from baseline was -22.1 +/- 2.1 kg (P < 0.0001) corresponding to 19.9 +/- 1.8% of total body weight and 47.0 +/- 4.4% excess of weight loss. There were also significant improvements in waist circumference, blood pressure, total and low-density lipoprotein cholesterol, triglycerides, and fasting glucose.
dc.description.abstractConclusions: The DJBL is safe when implanted for 1 year, and results in significant weight loss and improvements in cardiometabolic risk factors. These results suggest that this device may be suitable for the treatment of morbid obesity and its related comorbidities. This study was registered at www.clinicaltrials.gov (NCT00985491).
dc.description.funderGI Dynamics Inc, Lexington, MA
dc.fechaingreso.objetodigital2024-05-23
dc.format.extent6 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1097/SLA.0b013e31825498c4
dc.identifier.eissn1528-1140
dc.identifier.issn0003-4932
dc.identifier.pubmedidMEDLINE:22534421
dc.identifier.urihttps://doi.org/10.1097/SLA.0b013e31825498c4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77723
dc.identifier.wosidWOS:000304101100020
dc.information.autorucMedicina;Bambs C;S/I;89631
dc.information.autorucMedicina;Becerra P;S/I;6724
dc.information.autorucMedicina;Escalona A;S/I;94025
dc.information.autorucMedicina;Ibañez L;S/I;99661
dc.information.autorucMedicina;Muñoz R;S/I;1004083
dc.information.autorucMedicina;Pimentel F;S/I;58222
dc.information.autorucMedicina;Sharp A;S/I;60632
dc.information.autorucMedicina;Slako M;S/I;85747
dc.information.autorucMedicina;Turiel D;S/I;93415
dc.issue.numero6
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1085
dc.pagina.inicio1080
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.revistaANNALS OF SURGERY
dc.rightsacceso restringido
dc.subjectLONG-TERM MORTALITY
dc.subjectBARIATRIC SURGERY
dc.subjectGASTRIC BYPASS
dc.subjectLOSS MAINTENANCE
dc.subjectUS ADULTS
dc.subjectMULTICENTER
dc.subjectPREVALENCE
dc.subjectHEALTH
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleWeight Loss and Metabolic Improvement in Morbidly Obese Subjects Implanted for 1 Year With an Endoscopic Duodenal-Jejunal Bypass Liner
dc.typeartículo
dc.volumen255
sipa.codpersvinculados89631
sipa.codpersvinculados6724
sipa.codpersvinculados94025
sipa.codpersvinculados99661
sipa.codpersvinculados1004083
sipa.codpersvinculados58222
sipa.codpersvinculados60632
sipa.codpersvinculados85747
sipa.codpersvinculados93415
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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