Genes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseases

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dc.contributor.authorGutierrez, Maria J.
dc.contributor.authorPerez, Geovanny F.
dc.contributor.authorGomez, Jose L.
dc.contributor.authorRodriguez‐Martinez, Carlos E.
dc.contributor.authorCastro‐Rodriguez, Jose A.
dc.contributor.authorNino, Gustavo
dc.date.accessioned2023-05-19T20:49:13Z
dc.date.available2023-05-19T20:49:13Z
dc.date.issued2021
dc.description.abstractOver the past decade, "omics" approaches have advanced our understanding of the molecular programming of the airways in humans. Several studies have identified potential molecular mechanisms that contribute to early life epigenetic reprogramming, including DNA methylation, histone modifications, microRNAs, and the homeostasis of the respiratory mucosa (epithelial function and microbiota). Current evidence supports the notion that early infancy is characterized by heightened susceptibility to airway genetic reprogramming in response to the first exposures in life, some of which can have life-long consequences. Here, we summarize and analyze the latest insights from studies that support a novel epigenetic paradigm centered on human maturational and developmental programs including three cardinal elements: genes, environment, and developmental timing. The combination of these factors is likely responsible for the functional trajectory of the respiratory system at the molecular, functional, and clinical levels.
dc.fechaingreso.objetodigital2025-04-29
dc.fuente.origenORCID-mayo23
dc.identifier.doi10.1002/ppul.25598
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70004
dc.identifier.urihttps://doi.org/10.1002/ppul.25598
dc.identifier.wosidWOS:000684642600001
dc.issue.numeroNo. 10
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final3165
dc.pagina.inicio3157
dc.revistaPediatric Pulmonology
dc.rightsacceso restringido
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGenes, environment, and developmental timing: New insights from translational approaches to understand early origins of respiratory diseaseses_ES
dc.typeartículo
dc.volumenVol. 56
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