The Cannabinoid System as a Potential Novel Target for Alcohol‐Associated Liver Disease: A Propensity‐Matched Cohort Study

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dc.catalogadorgrr
dc.contributor.authorFakhoury, Butros
dc.contributor.authorJahagirdar, Vinay
dc.contributor.authorRama, Kaanthi
dc.contributor.authorHudson, David
dc.contributor.authorWang, Wei
dc.contributor.authorDiaz Piga, Luis Antonio
dc.contributor.authorArab Verdugo, Juan Pablo
dc.date.accessioned2025-10-29T19:52:12Z
dc.date.available2025-10-29T19:52:12Z
dc.date.issued2025
dc.description.abstractBackground: Alcohol-associated liver disease (ALD) is a leading cause of liver-related morbidity and mortality, yet effectivetherapeutic options remain limited. Preclinical data suggest that modulation of the hepatic endocannabinoid system, particularlyvia cannabidiol (CBD), may reduce alcohol-induced liver injury. Due to CBD's limited clinical use, we sought to evaluate the as-sociation between cannabis use and ALD risk among patients with alcohol use disorder (AUD).Methods: Using the TriNetX US Collaborative Network, we identified adult patients with AUD between 2010 and 2022. Threecohorts were constructed: cannabis use disorder (CUD), cannabis users without cannabis abuse or dependence (CU) and non-cannabis users (non- CU). Outcomes included ALD, hepatic decompensation and composite all-cause mortality over 3 years.Incidence and hazard ratios were calculated using Kaplan–Meier analysis and Cox regression.Results: After matching, 33 114 patients were included in each of the CUD and non- CU groups. Compared to non- CU, CUD wasassociated with a lower risk of ALD (HR 0.60, 95% CI 0.53–0.67; p < 0.001), hepatic decompensation (HR 0.83, 95% CI 0.73–0.95;p =0.005) and all-cause mortality (HR 0.86, 95% CI 0.80–0.94; p < 0.001) among individuals with AUD. Although CU was asso-ciated with lower risks of ALD, its risks of hepatic decompensation and all-cause mortality were similar to those of the non- CUcohort with AUD.
dc.fechaingreso.objetodigital2025-10-29
dc.format.extent14 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1111/liv.70401
dc.identifier.eissn1478-3231
dc.identifier.issn1478-3223
dc.identifier.urihttps://doi.org/10.1111/liv.70401
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/106398
dc.identifier.wosidWOS:001597927400001
dc.information.autorucEscuela de Medicina; Diaz Piga, Luis Antonio; 0000-0002-8540-4930; 179253
dc.information.autorucEscuela de Medicina; Arab Verdugo, Juan Pablo; 0000-0002-8561-396X; 132745
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaLiver International
dc.rightsacceso abierto
dc.subjectCannabidiol
dc.subjectEndocannabinoid system
dc.subjectFibrogenesis
dc.subjectHepatic stellate cells
dc.subjectLipogenesis
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleThe Cannabinoid System as a Potential Novel Target for Alcohol‐Associated Liver Disease: A Propensity‐Matched Cohort Study
dc.typeartículo
sipa.codpersvinculados179253
sipa.codpersvinculados132745
sipa.trazabilidadORCID;2025-10-27
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