Type 1 Corticotropin-Releasing Factor Receptor Differentially Modulates Neurotransmitter Levels in the Nucleus Accumbens of Juvenile versus Adult Rats

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dc.contributor.authorZegers-Delgado, Juan
dc.contributor.authorAguilera-Soza, Alejandro
dc.contributor.authorCalderon, Florencia
dc.contributor.authorDavidson, Harley
dc.contributor.authorVerbel-Vergara, Daniel
dc.contributor.authorYarur, Hector E.
dc.contributor.authorNovoa, Javier
dc.contributor.authorBlanlot, Camila
dc.contributor.authorBastias, Cristian P.
dc.contributor.authorEstela Andres, Maria
dc.contributor.authorGysling, Katia
dc.date.accessioned2025-01-20T21:02:35Z
dc.date.available2025-01-20T21:02:35Z
dc.date.issued2022
dc.description.abstractAdversity is particularly pernicious in early life, increasing the likelihood of developing psychiatric disorders in adulthood. Juvenile and adult rats exposed to social isolation show differences in anxiety-like behaviors and significant changes in dopamine (DA) neurotransmission in the nucleus accumbens (NAc). Brain response to stress is partly mediated by the corticotropin-releasing factor (CRF) system, composed of CRF and its two main receptors, CRF-R1 and CRF-R2. In the NAc shell of adult rats, CRF induces anxiety-like behavior and changes local DA balance. However, the role of CRF receptors in the control of neurotransmission in the NAc is not fully understood, nor is it known whether there are differences between life stages. Our previous data showed that infusion of a CRF-R1 antagonist into the NAc of juvenile rats increased DA levels in response to a depolarizing stimulus and decreased basal glutamate levels. To extend this analysis, we now evaluated the effect of a CRF-R1 antagonist infusion in the NAc of adult rats. Here, we describe that the opposite occurred in the NAc of adult compared to juvenile rats. Infusion of a CRF-R1 antagonist decreased DA and increased glutamate levels in response to a depolarizing stimulus. Furthermore, basal levels of DA, glutamate, and gamma-Aminobutyric acid (GABA) were similar in juvenile animals compared to adults. CRF-R1 protein levels and localization were not different in juvenile compared to adult rats. Interestingly, we observed differences in the signaling pathways of CRF-R1 in the NAc of juveniles compared to adult rats. We propose that the function of CRF-R1 receptors is differentially modulated in the NAc according to life stage.
dc.fuente.origenWOS
dc.identifier.doi10.3390/ijms231810800
dc.identifier.eissn1422-0067
dc.identifier.issn1661-6596
dc.identifier.urihttps://doi.org/10.3390/ijms231810800
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93056
dc.identifier.wosidWOS:000856391500001
dc.issue.numero18
dc.language.isoen
dc.revistaInternational journal of molecular sciences
dc.rightsacceso restringido
dc.subjectCRF receptor 1
dc.subjectjuvenile versus adult rats
dc.subjectnucleus accumbens neurotransmitter levels
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleType 1 Corticotropin-Releasing Factor Receptor Differentially Modulates Neurotransmitter Levels in the Nucleus Accumbens of Juvenile versus Adult Rats
dc.typeartículo
dc.volumen23
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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