Implementation of a liver health check in people with type 2 diabetes

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dc.contributor.authorAbeysekera, Kushala W. M.
dc.contributor.authorValenti, Luca
dc.contributor.authorYounossi, Zobair
dc.contributor.authorDillon, John F.
dc.contributor.authorAllen, Alina M.
dc.contributor.authorNoureddin, Mazen
dc.contributor.authorRinella, Mary E.
dc.contributor.authorTacke, Frank
dc.contributor.authorFrancque, Sven
dc.contributor.authorGines, Pere
dc.contributor.authorThiele, Maja
dc.contributor.authorNewsome, Philip N.
dc.contributor.authorGuha, Indra Neil
dc.contributor.authorEslam, Mohammed
dc.contributor.authorSchattenberg, Joern M.
dc.contributor.authorAlqahtani, Saleh A.
dc.contributor.authorArrese, Marco
dc.contributor.authorBerzigotti, Annalisa
dc.contributor.authorHolleboom, Adriaan G.
dc.contributor.authorCaussy, Cyrielle
dc.contributor.authorCusi, Kenneth
dc.contributor.authorRoden, Michael
dc.contributor.authorHagstroem, Hannes
dc.contributor.authorWong, Vincent Wai-Sun
dc.contributor.authorMallet, Vincent
dc.contributor.authorCastera, Laurent
dc.contributor.authorLazarus, Jeffrey V.
dc.contributor.authorTsochatzis, Emmanuel A.
dc.date.accessioned2025-01-20T17:08:23Z
dc.date.available2025-01-20T17:08:23Z
dc.date.issued2024
dc.description.abstractAs morbidity and mortality related to potentially preventable liver diseases are on the rise globally, early detection of liver fibrosis offers a window of opportunity to prevent disease progression. Early detection of non-alcoholic fatty liver disease allows for initiation and reinforcement of guidance on bodyweight management, risk stratification for advanced liver fibrosis, and treatment optimisation of diabetes and other metabolic complications. Identification of alcohol-related liver disease provides the opportunity to support patients with detoxification and abstinence programmes. In all patient groups, identification of cirrhosis ensures that patients are enrolled in surveillance programmes for hepatocellular carcinoma and portal hypertension. When considering early detection strategies, success can be achieved from applying ad-hoc screening for liver fibrosis in established frameworks of care. Patients with type 2 diabetes are an important group to consider case findings of advanced liver fibrosis and cirrhosis, as up to 19% have advanced fibrosis (which is ten times higher than the general population) and almost 70% have non-alcoholic fatty liver disease. Additionally, patients with type 2 diabetes with alcohol use disorders have the highest proportion of liver-related morbidity of people with type 2 diabetes generally. Patients with type 2 diabetes receive an annual diabetes review as part of their routine clinical care, in which the health of many organs are considered. Yet, liver health is seldom included in this review. This Viewpoint argues that augmenting the existing risk stratification strategy with an additional liver health check provides the opportunity to detect advanced liver fibrosis, thereby opening a window for early interventions to prevent end-stage liver disease and its complications, including hepatocellular carcinoma
dc.fuente.origenWOS
dc.identifier.doi10.1016/S2468-1253(23)00270-4
dc.identifier.eissn2468-1253
dc.identifier.urihttps://doi.org/10.1016/S2468-1253(23)00270-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90945
dc.identifier.wosidWOS:001162890700001
dc.issue.numero1
dc.language.isoen
dc.pagina.final91
dc.pagina.inicio83
dc.revistaLancet gastroenterology & hepatology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleImplementation of a liver health check in people with type 2 diabetes
dc.typeartículo
dc.volumen9
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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