Hosts and vectors of scrub typhus in Chile: epidemiological study and molecular analyses of Orientia infection in rodents and rodent-associated mites

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dc.article.number514
dc.catalogadoraba
dc.contributor.authorMartínez Valdebenito, Constanza
dc.contributor.authorAcosta-Jamett, Gerardo
dc.contributor.authorAbello, Rayitray
dc.contributor.authorJiang, Ju
dc.contributor.authorRichards, Allen L.
dc.contributor.authorAbarca Villaseca, Katia
dc.contributor.authorWeitzel, Thomas
dc.date.accessioned2024-12-30T13:35:29Z
dc.date.available2024-12-30T13:35:29Z
dc.date.issued2024
dc.date.updated2024-12-22T01:04:51Z
dc.description.abstractAbstract Candidatus Orientia chiloensis causes scrub typhus over a wide geographical range in southern Chile. The life cycle, including vectors and reservoirs of this novel rickettsial pathogen, is incompletely understood. We analyzed rodent tissue and rodent-associated mite samples collected during a field study in six localities on Chiloé Island, where human scrub typhus cases have occurred. Using molecular methods, we detected Orientia DNA in 24.8% of rodents, belonging to five of seven captured species. Orientia-infection rates showed geographical variations, but were not influenced by rodent species, sex, age, and mite infestation. Phylogenetic analysis showed that Orientia sequences from trombiculid mites (Proschoengastia eloisae) were identical to those from scrub typhus patients from the same region. The results suggest that these rodent-associated mites serve as vectors and play an important role in the ecology of scrub typhus in southern Chile. Further studies are required to determine whether Orientia-infected rodents can also serve as reservoir of Orientia in Chile. Graphical Abstract
dc.fechaingreso.objetodigital2024-12-19
dc.format.extent8 páginas
dc.fuente.origenAutoarchivo
dc.identifier.doi10.1186/s13071-024-06602-0
dc.identifier.issn1756-3305
dc.identifier.scopusid2-s2.0-85212524864
dc.identifier.urihttps://doi.org/10.1186/s13071-024-06602-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/89355
dc.identifier.wosidWOS:001381012900008
dc.information.autorucEscuela de Medicina; Martínez Valdebenito, Constanza; S/I; 1007539
dc.information.autorucEscuela de Medicina; Abarca Villaseca, Katia; 0000-0003-0404-3887; 70281
dc.issue.numero1
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final8
dc.pagina.inicio1
dc.revistaParasites & Vectors
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectScrub typhus
dc.subjectVector-borne diseases
dc.subjectZoonotic diseases
dc.subjectRickettsiales
dc.subjectEpidemiology
dc.subjectSouth America
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHosts and vectors of scrub typhus in Chile: epidemiological study and molecular analyses of Orientia infection in rodents and rodent-associated mites
dc.typeartículo
dc.volumen17
sipa.codpersvinculados1007539
sipa.codpersvinculados70281
sipa.indexScopus
sipa.indexWOS
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