Clostridium difficile associated infections: an updated view

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dc.contributor.authorHernandez Rocha, Cristian
dc.contributor.authorNaour, Sebastian
dc.contributor.authorAlvarez Lobos, Manuel
dc.contributor.authorParedes Sabja, Daniel
dc.date.accessioned2024-01-10T12:38:04Z
dc.date.available2024-01-10T12:38:04Z
dc.date.issued2012
dc.description.abstractClostridium difficile is an emerging anaerobic, spore forming pathogen, recognized as the etiological agent of similar to 30% of antibiotic associated diarrheas. Clinical symptoms can fluctuate from mild to moderate diarrhea, pseudomembranous colitis and toxic megacolon. The incidence of C. difficile associated infections (CDAI) is similar to 1% of total hospitalized patients. CDAI has a mortality rate of similar to 1 to 5%, and a relapse rate of similar to 20%. The appearance of severe outbreaks of CDAI could be attributed to changes in the production of the two major virulence factors, the enterotoxins TcdA and TcdB, which produce massive epithelial damage. C. difficile spores play an essential role in transmission, initiation and persistence of CDAI. Recent advances in detection methods, development of novel therapies and prevention methods could allow a reduction on the frequency of CDAI. The objective of this review is to provide an updated view on the mechanisms of pathogenesis, epidemiology, risk factors, detection methods, treatment and prevention of CDAI.
dc.fechaingreso.objetodigital2024-05-30
dc.format.extent12 páginas
dc.fuente.origenWOS
dc.identifier.doi10.4067/S0716-10182012000400011
dc.identifier.eissn0717-6341
dc.identifier.issn0716-1018
dc.identifier.pubmedidMEDLINE:23096544
dc.identifier.urihttps://doi.org/10.4067/S0716-10182012000400011
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76979
dc.identifier.wosidWOS:000307987100011
dc.information.autorucMedicina;Alvarez M ;S/I;6131
dc.information.autorucMedicina;Hernandez C;S/I;175117
dc.issue.numero4
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final445
dc.pagina.inicio434
dc.publisherSOC CHILENA INFECTOLOGIA
dc.revistaREVISTA CHILENA DE INFECTOLOGIA
dc.rightsacceso abierto
dc.subjectC. difficile
dc.subjectCDAI
dc.subjectpseudomembranous colitis
dc.subjecttoxic megacolon
dc.subjectspores
dc.subjectantibiotic associated colitis
dc.subjectSURFACE-LAYER PROTEINS
dc.subjectREAL-TIME PCR
dc.subjectBILE-ACIDS
dc.subjectTOXIN-A
dc.subjectUNITED-STATES
dc.subjectRETAIL MEAT
dc.subjectDIARRHEA
dc.subjectDISEASE
dc.subjectRESISTANCE
dc.subjectVANCOMYCIN
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleClostridium difficile associated infections: an updated view
dc.typeartículo
dc.volumen29
sipa.codpersvinculados6131
sipa.codpersvinculados175117
sipa.indexWOS
sipa.indexScielo
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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