Demographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score

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dc.catalogadordfo
dc.contributor.authorReyes Placencia, Diego Armando
dc.contributor.authorMuñoz, Ana
dc.contributor.authorCandia Balboa, Roberto Andrés
dc.contributor.authorRey, Paula
dc.contributor.authorChahuan Abde, Javier Nicolás
dc.contributor.authorGran, Ignacio
dc.contributor.authorRemes-Troche, José María
dc.contributor.authorCisternas, Daniel
dc.contributor.authorMonrroy, Hugo
dc.date.accessioned2025-09-22T15:35:25Z
dc.date.available2025-09-22T15:35:25Z
dc.date.issued2025
dc.description.abstractObjective: Conclusive diagnosis of gastroesophageal reflux disease (GERD) can be challenging. When reflux monitoring is inconclusive, high-resolution esophageal manometry (HRM) may provide additional relevant information. We aimed to identify demographic and manometric parameters associated with GERD and to propose a diagnostic score. Methods: Adult patients with GERD symptoms who underwent reflux monitoring and HRM were considered for inclusion. The gold standard for GERD diagnosis was acid exposure time (AET); patients with AET>6% and AET<4% were included. Univariate and multivariate analyses were performed. A diagnostic score was developed using parameters independently associated with GERD. Generation and validation cohorts were randomly selected in a 2:1 ratio. Diagnostic accuracy was assessed using the area under the receiver operating characteristic curve (AUC ROC). Results: A total of 391 patients met the inclusion criteria; 167 had GERD (AET>6%) and 224 did not have GERD (AET<4%). In the multivariate analysis, age, male sex, and the distance between the lower esophageal sphincter and the crural diaphragm (LES-CD) were directly associated with GERD, while esophagogastric junction contractile integral (EGJ-CI) and distal contractile integral (DCI) were inversely associated with GERD (p values: 0.03, <0.01, <0.01, 0.01, and 0.01, respectively). The AUC ROC of a diagnostic score based on these parameters was 0.76 and 0.82 in the generation and validation cohorts, respectively. Conclusions: In this observational study, age, male sex, LES-CD distance, EGJ-CI, and DCI (AGES-D) were independently associated with GERD. A novel score incorporating these parameters could be useful in the assessment of inconclusive cases.
dc.fechaingreso.objetodigital2025-09-22
dc.format.extent8 páginas
dc.fuente.origenORCID
dc.identifier.doi10.7704/kjhugr.2025.0030
dc.identifier.urihttps://doi.org/10.7704/kjhugr.2025.0030
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105711
dc.information.autorucEscuela de Medicina; Reyes Placencia Diego Armando; 0000-0001-6371-3516; 194184
dc.information.autorucEscuela de Medicina; Candia Balboa Roberto Andres; 0000-0003-1856-7737; 16705
dc.information.autorucEscuela de Medicina; Chahuan Abde Javier Nicolas; N/A; 187210
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final283
dc.pagina.inicio276
dc.revistaThe Korean Journal of Helicobacter and Upper Gastrointestinal Research
dc.rightsacceso abierto
dc.subjectEsophagogastric junction
dc.subjectGastroesophageal reflux
dc.subjectEsophageal pH monitoring
dc.subjectManometry
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleDemographic and Manometric Variables Can Independently Predict Gastroesophageal Reflux Disease: The AGES-D Score
dc.typeartículo
dc.volumen25
sipa.codpersvinculados194184
sipa.codpersvinculados16705
sipa.codpersvinculados187210
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