Evaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk populationEvaluación de Trefoil factor 3 como un biomarcador no invasivo para la detección de metaplasia intestinal y cáncer gástrico en una población de alto riesgo

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dc.article.number1364000
dc.contributor.authorLatorre G.
dc.contributor.authorPizarro M.
dc.contributor.authorVargas J.I.
dc.contributor.authorEspino A.
dc.contributor.authorAguero C.
dc.contributor.authorGonzalez R.
dc.contributor.authorRiquelme A.
dc.contributor.authorGandara V.
dc.contributor.authorMunoz G.
dc.contributor.authorFord J.S.
dc.contributor.authorAraya J.C.
dc.contributor.authorBellolio E.
dc.contributor.authorVillaseca M.
dc.contributor.authorFuentes-Lopez E.
dc.contributor.authorCortes P.
dc.contributor.authorRollan A.
dc.contributor.authorBufadel M.E.
dc.contributor.authorAraya R.
dc.contributor.authorSharp A.
dc.contributor.authorDonoso A.
dc.contributor.authorBresky G.
dc.contributor.authorPedrero P.
dc.contributor.authorRueda C.
dc.contributor.authorCalvo A.
dc.contributor.authorParra-Blanco A.
dc.contributor.authorOdagaki T.
dc.contributor.authorMoriyama T.
dc.contributor.authorIshida T.
dc.contributor.authorCamargo M.C.
dc.contributor.authorCorvalan A.H.
dc.date.accessioned2024-10-15T07:00:16Z
dc.date.available2024-10-15T07:00:16Z
dc.date.issued2022
dc.description.abstract© 2022 Elsevier España, S.L.U.Background: Adenocarcinoma is preceded by chronic atrophic gastritis, gastric intestinal metaplasia and dysplasia. Trefoil factor 3 (TFF3) is a peptide secreted by goblet cells, which is abundantly present in intestinal metaplasia. Aim: To evaluate the utility of serum TFF3 as a non-invasive biomarker for the diagnosis of intestinal metaplasia and gastric cancer. Methods: Single-center, cross-sectional study of 274 patients who consecutively underwent upper gastrointestinal endoscopy with gastric biopsies (updated Sydney system). TFF3 levels were measured in serum by a commercial ELISA kit. Patients with normal histology or chronic atrophic gastritis without intestinal metaplasia comprised the control group. In addition, 14 patients with invasive gastric cancer were included as a reference group. The association between TFF3 levels and intestinal metaplasia was assessed by logistic regression. Results: Patients with intestinal metaplasia (n = 110) had a higher median TFF3 level as compared to controls (n = 164), 13.1 vs. 11.9 ng/mL, respectively (p = 0.024). Multivariable logistic regression showed a no significant association between TFF3 levels and intestinal metaplasia (OR = 1.20; 95%CI: 0.87–1.65; p-trend = 0.273). The gastric cancer group had a median TFF3 level of 20.5 ng/mL, and a significant association was found (OR = 3.26; 95%CI: 1.29–8.27; p-trend = 0.013). Conclusion: Serum levels of TFF3 do not discriminate intestinal metaplasia in this high-risk Latin American population. Nevertheless, we confirmed an association between TFF3 levels and invasive gastric cancer.
dc.description.funderAgencia Nacional de Investigaci?n y Desarrollo
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderCRIP
dc.description.funderFLUOMICS Consortium
dc.description.funderNIH
dc.description.funderNIAID
dc.description.funderFONDECYT
dc.format.extent559 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.gastrohep.2022.04.004
dc.identifier.eissn15789519
dc.identifier.issn2105705
dc.identifier.pubmedid35580739
dc.identifier.scopusidSCOPUS_ID:85132899822
dc.identifier.urihttps://doi.org/10.1016/j.gastrohep.2022.04.004
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/88225
dc.identifier.wosidWOS:001005226100001
dc.information.autorucFacultad de Medicina; Fuentes Lopez, Eduardo; S/I; 1013849
dc.issue.numero6
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final20
dc.pagina.inicio14
dc.relation.ispartofGastroenterologia y Hepatologia
dc.revistaGastroenterologia y Hepatologia
dc.rightsacceso cerrado
dc.subjectGastric cancer
dc.subjectIntestinal metaplasia
dc.subjectPrecancerous conditions
dc.subjectTrefoil factor 3
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvaluation of trefoil factor 3 as a non-invasive biomarker of gastric intestinal metaplasia and gastric cancer in a high-risk populationEvaluación de Trefoil factor 3 como un biomarcador no invasivo para la detección de metaplasia intestinal y cáncer gástrico en una población de alto riesgo
dc.typeartículo
dc.volumen12
sipa.codpersvinculados1013849
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;15-10-2024
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