Terapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación

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dc.catalogadorpva
dc.contributor.authorAcevedo Claros, Francisco Nicolás
dc.contributor.authorHerrera Nieda, Maria Elisa
dc.contributor.authorMadrid Arenas, Jorge
dc.contributor.authorSánchez Rojel, César Giovanni
dc.date.accessioned2024-01-19T18:21:51Z
dc.date.available2024-01-19T18:21:51Z
dc.date.issued2013
dc.description.abstractNeoadjuvant chemotherapy is an accepted strategyforpatients with locally advanced breast cáncer. This approach increases the possibilities ofconservative treatment and improves the resectability rates ofinitially unresectable tumors. In addition, preoperative systemic therapy allows the evaluation of prognostic and predictive factors, dynamically and in vivo. Since over 80% ofthese tumors express estrogen receptors (ER), endocrine therapy seems a logical treatment to employ in the neoadjuvant setting. The advent ofnew drugs that regúlate the ERfunction, along with the results of severa! clinical studies with the use of neoadjuvant endocrine therapy, support the feasibility and safety of utilizing this strategy before surgery. We herein analyze the available clinical evidence about the use of neoadjuvant therapy aiming to regúlate the activity ofthe ER. We also discuss the valué of predictive factors that could help the oncologist to select those patients most likely to benefit from this approach and the role of endocrine therapy as a research instrument.
dc.fechaingreso.objetodigital2024-01-31
dc.fuente.origenORCID-ene24
dc.identifier.doi10.4067/s0034-98872013000300013
dc.identifier.issn0034-9887
dc.identifier.urihttp://dx.doi.org/10.4067/s0034-98872013000300013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80819
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolas; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Acevedo Claros, Francisco Nicolás; 0000-0003-3482-7746; 119540
dc.information.autorucEscuela de Medicina; Herrera Nieda, Maria Elisa; S/I; 167361
dc.information.autorucEscuela de Medicina; Madrid Arenas, Jorge; S/I; 115522
dc.information.autorucEscuela de Medicina; Sánchez Rojel, César Giovanni; 0000-0002-2920-108X; 135644
dc.issue.numero3
dc.language.isoes
dc.nota.accesoContenido completo
dc.pagina.final374
dc.pagina.inicio367
dc.revistaRevista médica de Chile
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 DEED Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectBreast neoplasms
dc.subjectChemotherapy, adjuvant
dc.subjectReceptors, estrogen
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.titleTerapia endocrina neoadyuvante en cáncer de mama, una alternativa de tratamiento e investigación
dc.title.alternativeNeoadyuvant endocrine therapy in breast cancer
dc.typeartículo de revisión
dc.volumen141
sipa.codpersvinculados119540
sipa.codpersvinculados167361
sipa.codpersvinculados115522
sipa.codpersvinculados135644
sipa.trazabilidadORCID;2024-01-08
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