Carotid body chemoreceptors: physiology, pathology, and implications for health and disease

dc.contributor.authorIturriaga R.
dc.contributor.authorAlcayaga J.
dc.contributor.authorChapleau M.W.
dc.contributor.authorSomers V.K.
dc.date.accessioned2024-01-10T12:11:37Z
dc.date.available2024-01-10T12:11:37Z
dc.date.issued2021
dc.description.abstractThe carotid body (CB) is the main peripheral chemoreceptor for arterial respiratory gases O2 and CO2 and pH, eliciting reflex ventilatory, cardiovascular, and humoral responses to maintain homeostasis. This review examines the fundamental biology underlying CB chemoreceptor function, its contribution to integrated physiological responses, and its role in maintaining health and potentiating disease. Emphasis is placed on 1) transduction mechanisms in chemoreceptor (type I) cells, highlighting the role played by the hypoxic inhibition of O2-dependent K+ channels and mitochondrial oxidative metabolism, and their modification by intracellular molecules and other ion channels; 2) synaptic mechanisms linking type I cells and petrosal nerve terminals, focusing on the role played by the main proposed transmitters and modulatory gases, and the participation of glial cells in regulation of the chemosensory process; 3) integrated reflex responses to CB activation, emphasizing that the responses differ dramatically depending on the nature of the physiological, pathological, or environmental challenges, and the interactions of the chemoreceptor reflex with other reflexes in optimizing oxygen delivery to the tissues; and 4) the contribution of enhanced CB chemosensory discharge to autonomic and cardiorespiratory pathophysiology in obstructive sleep apnea, congestive heart failure, resistant hypertension, and metabolic diseases and how modulation of enhanced CB reactivity in disease conditions may attenuate pathophysiology.
dc.fechaingreso.objetodigital2024-05-14
dc.fuente.origenScopus
dc.identifier.doi10.1152/physrev.00039.2019
dc.identifier.eissn15221210
dc.identifier.issn15221210
dc.identifier.pubmedid33570461
dc.identifier.scopusidSCOPUS_ID:85107710767
dc.identifier.urihttps://doi.org/10.1152/physrev.00039.2019
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76671
dc.identifier.wosidWOS:000661586400007
dc.information.autorucFacultad de Ciencias Biológicas; Iturriaga Aguera, Rodrigo Manuel; S/I; 59784
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final1235
dc.pagina.inicio1177
dc.publisherNLM (Medline)
dc.revistaPhysiological reviews
dc.rightsacceso restringido
dc.subjectautonomic system
dc.subjectcarotid body
dc.subjecthypoxia
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCarotid body chemoreceptors: physiology, pathology, and implications for health and disease
dc.typeartículo
dc.volumen101
sipa.codpersvinculados59784
sipa.indexScopus
sipa.indexPubmed
sipa.trazabilidadCarga SIPA;09-01-2024
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