PLATELET AUTOANTIBODIES IN PATIENTS WITH CHRONIC LIVER-DISEASE

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dc.contributor.authorPEREIRA, J
dc.contributor.authorACCATINO, L
dc.contributor.authorALFARO, J
dc.contributor.authorBRAHM, J
dc.contributor.authorHIDALGO, P
dc.contributor.authorMEZZANO, D
dc.date.accessioned2025-01-21T01:34:23Z
dc.date.available2025-01-21T01:34:23Z
dc.date.issued1995
dc.description.abstractThe thrombocytopenia in chronic liver disease (CLD) has been attributed mainly to hypersplenism, although other factors such as reduced mean life span with increased platelet turnover have also been demonstrated, Immunological abnormalities have been described in the pathogenesis and progression of CLD. In this sense, many studies have reported elevated levels of platelet associated IgG (PAIgG) in patients with CLD, and it has been suggested that PAIgG could represent true antiplatelet antibody. In this study we used a glycoprotein (GP)-specific immunoassay (MACE) to determine whether PAIgG or circulating antiplatelet antibodies, reacted against the GPIIb/IIIa or GPIb/IX complexes, in patients with CLD. Thirty-six patients with CLD of diverse etiology were studied (20 female, mean age 53 years, range 38-75 years). 23 out of 36 patients (64%) had anti-GP antibodies in MACE, Particularly, 12 had anti-GPIb, 4 anti-GPIIb/IIIa, and 7 had both types of autoantibodies, The existence of these anti-GP antibodies was not related with the blood platelet count or etiology of CLD,
dc.description.abstractThese data show that in patients with CLD of diverse origin, there is a high prevalence of autoantibodies reacting specifically with platelet membrane GP, which constitutes the first evidence of the specific nature of platelet-bound IgG in CLD. These findings suggest that in patients with CLD, an immune mechanism may participate in inducing or aggravating the thrombocytopenia. (C) 1995 Wiley-Liss, Inc.
dc.fuente.origenWOS
dc.identifier.issn0361-8609
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97552
dc.identifier.wosidWOS:A1995TB94200004
dc.issue.numero3
dc.language.isoen
dc.pagina.final178
dc.pagina.inicio173
dc.revistaAmerican journal of hematology
dc.rightsacceso restringido
dc.subjectTHROMBOCYTOPENIA
dc.subjectLIVER DISEASE
dc.subjectAUTOANTIBODIES
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePLATELET AUTOANTIBODIES IN PATIENTS WITH CHRONIC LIVER-DISEASE
dc.typeartículo
dc.volumen50
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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