Human Anterior Insula Encodes Performance Feedback and Relays Prediction Error to the Medial Prefrontal Cortex

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dc.contributor.authorBilleke, Pablo
dc.contributor.authorOssandon, Tomas
dc.contributor.authorPerrone-Bertolotti, Marcela
dc.contributor.authorKahane, Philippe
dc.contributor.authorBastin, Julien
dc.contributor.authorJerbi, Karim
dc.contributor.authorLachaux, Jean-Philippe
dc.contributor.authorFuentealba, Pablo
dc.date.accessioned2025-01-23T19:47:56Z
dc.date.available2025-01-23T19:47:56Z
dc.date.issued2020
dc.description.abstractAdaptive behavior requires the comparison of outcome predictions with actual outcomes (e.g., performance feedback). This process of performance monitoring is computed by a distributed brain network comprising the medial prefrontal cortex (mPFC) and the anterior insular cortex (AIC). Despite being consistently co-activated during different tasks, the precise neuronal computations of each region and their interactions remain elusive. In order to assess the neural mechanism by which the AIC processes performance feedback, we recorded AIC electrophysiological activity in humans. We found that the AIC beta oscillations amplitude is modulated by the probability of performance feedback valence (positive or negative) given the context (task and condition difficulty). Furthermore, the valence of feedback was encoded by delta waves phase-modulating the power of beta oscillations. Finally, connectivity and causal analysis showed that beta oscillations relay feedback information signals to the mPFC. These results reveal that structured oscillatory activity in the anterior insula encodes performance feedback information, thus coordinating brain circuits related to reward-based learning.
dc.fuente.origenWOS
dc.identifier.doi10.1093/cercor/bhaa017
dc.identifier.eissn1460-2199
dc.identifier.issn1047-3211
dc.identifier.urihttps://doi.org/10.1093/cercor/bhaa017
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100414
dc.identifier.wosidWOS:000574296400012
dc.issue.numero7
dc.language.isoen
dc.pagina.final4025
dc.pagina.inicio4011
dc.revistaCerebral cortex
dc.rightsacceso restringido
dc.subjectbeta oscillations
dc.subjecterror monitoring
dc.subjectfeedback
dc.subjectinsula
dc.subjectintracortical recording
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHuman Anterior Insula Encodes Performance Feedback and Relays Prediction Error to the Medial Prefrontal Cortex
dc.typeartículo
dc.volumen30
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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