After surgically induced remission, ileal and colonic mucosa-associated microbiota predicts Crohn’s disease recurrence

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dc.catalogadoryvc
dc.contributor.authorHernández Rocha, Cristian Antonio
dc.contributor.authorTurpin, Williams
dc.contributor.authorBorowski, Krzysztof
dc.contributor.authorStempak, Joanne M.
dc.contributor.authorSabic, Ksenija
dc.contributor.authorGettler, Kyle
dc.contributor.authorTastad, Christopher
dc.contributor.authorChasteau, Colleen
dc.contributor.authorKorie, Ujunwa
dc.contributor.authorHanna, Mary
dc.contributor.authorKhan, Abdul
dc.contributor.authorMengesha, Emebet
dc.contributor.authorBitton, Alain
dc.contributor.authorSchwartz, Marc B.
dc.contributor.authorBarrie, Arthur
dc.contributor.authorDatta, Lisa W.
dc.contributor.authorLazarev, Mark
dc.contributor.authorBrant, Steven R.
dc.contributor.authorRioux, John D.
dc.contributor.authorMcGovern, Dermot P.B.
dc.contributor.authorDuerr, Richard H.
dc.contributor.authorSchumm L., Phil
dc.contributor.authorCho, Judy H.
dc.contributor.authorSilverberg, Mark S.
dc.date.accessioned2024-07-18T15:17:42Z
dc.date.available2024-07-18T15:17:42Z
dc.date.issued2024
dc.description.abstractBackground and aims. Investigating the tissue-associated microbiota after surgically induced remission may help to understand the mechanisms initiating intestinal inflammation in Crohn’s disease. Methods: Crohn’s disease patients undergoing ileocolic resection were prospectively recruited in six academic centers. Biopsy samples from the neoterminal ileum, colon and rectosigmoid were obtained from colonoscopies performed after surgery. Microbial DNA was extracted for rRNA gene sequencing. Microbial diversity and taxonomic differential relative abundance were analyzed. A random forest model was applied to analyze the performance of clinical and microbial features to predict recurrence. A Rutgeerts score ≥i2 was deemed as endoscopic recurrence. Results: A total of 349 postoperative colonoscopies and 944 biopsy samples from 262 Crohn’s disease patients were analyzed. Ileal inflammation accounted for most of the explained variance of the ileal and colonic mucosa-associated microbiota. Samples obtained from 97 patients who were in surgically induced remission at first postoperative colonoscopy who went on to develop endoscopic recurrence at second colonoscopy showed lower diversity and microbial deviations when compared to patients who remained in endoscopic remission. Depletion of genus Anaerostipes and increase of several genera from class Gammaproteobacteria at the three biopsy sites increase the risk of further recurrence. Gut microbiome was able to predict future recurrence better than clinical features. Conclusion: Ileal and colonic mucosa-associated microbiome deviations precede development of new onset ileal inflammation after surgically induced remission and show good predictive performance for future recurrence. These findings suggest that targeted microbial modulation is a plausible modality to prevent postoperative Crohn’s disease recurrence.
dc.description.funderNational Institute of Diabetes and Digestive and Kidney Diseases [NIDDK] of the National Institutes of Health [NIH] ]: grant U01 DK062431 to S.R.B
dc.description.funderANID FONDECYT No. 1230757
dc.format.extent42 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.cgh.2024.06.022
dc.identifier.urihttps://doi.org/10.1016/j.cgh.2024.06.022
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87111
dc.information.autorucEscuela de Medicina;Hernández Rocha, Cristian Antonio;0000-0001-9018-4242;175117
dc.language.isoen
dc.nota.accesocontenido parcial
dc.rightsacceso restringido
dc.subjectCrohn’s disease
dc.subjectMicrobiota
dc.subjectDisease recurrence
dc.subjectPrediction
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAfter surgically induced remission, ileal and colonic mucosa-associated microbiota predicts Crohn’s disease recurrence
dc.typeartículo
sipa.codpersvinculados175117
sipa.trazabilidadORCID;2024-07-15
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