A new example of 1α-hydroxylation of drimanic terpenes through combined microbial and chemical processes
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Date
2001
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Abstract
Among various filamentous fungi, Aspergillus niger ATCC 9142 was the most efficient strain to convert confertifolin in high yield into its 3 beta -hydroxy derivative, which was then chemically converted to 1 alpha -hydroxy-, 1 alpha ,11 alpha -dihydroxy- and 1 alpha -acetoxy-11 alpha -hydroxyconfertifolin, new compounds structurally related to bioactive natural products isolated from plants or marine sponges. (C) 2001 Elsevier Science Ltd. All rights reserved.
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Keywords
confertifolin, biotransformation, microbial hydroxylation, functionalization transfer